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首页> 外文期刊>Frontiers in neuroendocrinology >The orexin/hypocretin system: a critical regulator of neuroendocrine and autonomic function.
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The orexin/hypocretin system: a critical regulator of neuroendocrine and autonomic function.

机译：Orexin / hypocretin系统：神经内分泌和自主神经功能的关键调节器。

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The hypocretins/orexins are hypothalamic peptides most recognized for their significant effects on feeding and arousal. Indeed, loss of the peptides results in a cataplexy quite similar to that observed canine models of human narcolepsy. However, neurons producing these peptides project to numerous brain sites known to be important in neuroendocrine regulation of pituitary function and autonomic centers as well. Results from numerous laboratories have suggested broad physiological roles for the hypocretins/orexins in neuroendocrine and autonomic regulation as a consequence of actions in the dorsal vagal complex, paraventricular nucleus, and pituitary. This review focuses upon evidence for potential physiologic roles for the peptides in these sites.
机译：降血糖素/食欲激素是下丘脑肽，因其对摄食和唤醒的显着作用而最广为人知。的确，肽的丢失导致了与人的发作性睡病犬模型非常相似的猝倒。然而，产生这些肽的神经元投射到许多大脑部位，这些部位在垂体功能和自主神经的神经内分泌调节中也很重要。许多实验室的研究结果表明，由于背迷走神经复合体，脑室旁核和垂体的作用，降钙素/ orexin在神经内分泌和自主神经调节中具有广泛的生理作用。这篇综述集中于这些位点中肽潜在的生理作用的证据。

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