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首页> 外文期刊>Frontiers in neuroendocrinology >Integration of the regulation of reproductive function and energy balance: lactation as a model.
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Integration of the regulation of reproductive function and energy balance: lactation as a model.

机译：生殖功能和能量平衡调节的整合：以泌乳为模型。

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Lactation is a physiological model for studying how the hypothalamus integrates peripheral signals, such as sensory signals (suckling stimulus) and those denoting energy balance (leptin), to alter hypothalamic function regulating food intake/energy balance and reproduction. The characteristics of food intake/energy balance during lactation are extreme hyperphagia, coupled with negative energy balance. The arcuate nucleus Neuropeptide Y (ARH-NPY) system is activated by: (1) brainstem projections specifically activated by the suckling stimulus, and (2) the decrease in leptin in response to the metabolic drain of milk production. NPY neurons from the ARH make direct contact with GnRH neurons and with CRH neurons in the PVH. NPY neurons also make contact with orexin and MCH neurons in the LHA, which, in turn, make contacts with GnRH neurons. Thus, the ARH-NPY system provides a neuroanatomical framework by which to integrate changes in food intake/energy with the regulation of cyclic reproductive function.
机译：泌乳是一种生理模型，用于研究下丘脑如何整合周围信号，例如感觉信号（乳头刺激）和表示能量平衡的信号（瘦素），以改变调节食物摄入/能量平衡和繁殖的下丘脑功能。哺乳期食物摄入/能量平衡的特征是极度食欲亢进，加上负能量平衡。弓形核神经肽Y（ARH-NPY）系统可通过以下方式激活：（1）乳刺激特别激活脑干突起，以及（2）响应牛奶生产代谢消耗的瘦素减少。来自ARH的NPY神经元直接与PVH中的GnRH神经元和CRH神经元接触。 NPY神经元还与LHA中的orexin和MCH神经元接触，而后者又与GnRH神经元接触。因此，ARH-NPY系统提供了一个神经解剖学框架，通过它可以将食物摄入/能量的变化与循环生殖功能的调节相结合。

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