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首页> 外文期刊>Trends in Cell Biology >Tubulogeneis in the developing mammalian kidney [Review]
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Tubulogeneis in the developing mammalian kidney [Review]

机译：发育中的哺乳动物肾中的肾小球成纤维细胞[综述]

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摘要

How do fibroblasts spontaneously organize into a polarized epithelial tube? This question has fascinated scientists studying the mammalian kidney for more than 40 years. The formation of epithelial tubules in the developing mammalian kidney involves both the aggregation of mesenchymal cells and their conversion into polarized epithelium, as well as the growth and branching morphogenesis of existing epithelium. The interactions among mesenchyme, epithelia and, more recently, the stroma, halve been well characterized and provide novel insights into the regulatory mechanisms underlying complex organ development. Cell signaling pathways and transcription factors have been defined through genetic and biochemical assays such that a picture of early kidney tubulogenesis is beginning to emerge.
机译：成纤维细胞如何自发组织成极化的上皮管？这个问题吸引了研究哺乳动物肾脏超过40年的科学家。发育中的哺乳动物肾脏中上皮小管的形成既涉及间充质细胞的聚集及其向极化上皮的转化，也涉及现有上皮的生长和分支形态发生。间充质，上皮细胞和最近，间质之间的相互作用已被很好地表征，并提供了复杂器官发育的调控机制的新见解。已经通过遗传和生化测定法定义了细胞信号传导途径和转录因子，从而开始出现早期肾小管生成的图像。

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