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首页> 外文期刊>Pediatric blood & cancer >Successful treatment of refractory immune hemolysis following unrelated cord blood transplant with Campath-1H.
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Successful treatment of refractory immune hemolysis following unrelated cord blood transplant with Campath-1H.

机译：使用Campath-1H进行无关的脐血移植后成功治疗难治性免疫溶血。

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Immune-mediated hemolytic anemia is a well-recognized complication of hematopoietic stem cell transplantation. We report on a 6-year-old boy with X-linked adrenoleukodystrophy who developed severe delayed alloimmune hemolytic anemia associated with immune-mediated neutropenia and thrombocytopenia following major ABO incompatible unrelated cord blood transplantation. The patient's cytopenias were refractory to treatment with corticosteroids, cyclosporine, intravenous immune globulin, rituximab, and pentostatin. After one course of Campath-1H his hematologic parameters normalized, suggesting that the compound may be an effective therapy for complex immunohematologic disorders complicating hematopoietic stem cell transplantation. The case also emphasizes the importance of T-cells in transplant associated immune cytopenias.
机译：免疫介导的溶血性贫血是造血干细胞移植的公认并发症。我们报道了一个6岁男孩，患有X联肾上腺皮质营养不良症，在严重的ABO不相容无关脐带血移植后，发生了与免疫介导的中性粒细胞减少症和血小板减少症相关的严重的延迟性同种免疫溶血性贫血。患者的血细胞减少症对皮质类固醇，环孢素，静脉内免疫球蛋白，利妥昔单抗和喷喷他汀治疗无效。经过一个疗程的Campath-1H后，他的血液学参数恢复正常，这表明该化合物可能是治疗复杂的造血干细胞移植的复杂免疫血液学疾病的有效方法。该案例还强调了T细胞在与移植相关的免疫性血细胞减少症中的重要性。

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