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首页> 外文期刊>PACE: Pacing and clinical electrophysiology >Spatial distribution of repolarization and depolarization abnormalities evaluated by body surface potential mapping in patients with Brugada syndrome.
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Spatial distribution of repolarization and depolarization abnormalities evaluated by body surface potential mapping in patients with Brugada syndrome.

机译：通过Brugada综合征患者体表电位图评估复极化和去极化异常的空间分布。

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BACKGROUND: Mutations in sodium channel gene, SCN5A, have been identified in Brugada syndrome, but it is still unclear as to how sodium channel dysfunction relates to arrhythmogenesis. We examined spatial distribution of both repolarization and depolarization abnormalities in patients with Brugada syndrome by using 87-leads body surface potential mapping (BSPM). METHODS: BSPM was recorded under baseline condition and after pharmacological interventions in 28 patients with Brugada syndrome (27 males, 49 +/- 14 years). The ST-segment amplitude 20 ms after the end of QRS (ST20), QRS duration, and corrected recovery time (RTc) were measured in all 87-leads, and averaged among 6-leads (D-F, 5-6) reflecting right ventricular outflow tract (RVOT) potentials and the other 81-leads. RESULTS: The ST20 was elevated at baseline, normalized by isoproterenol, and augmented by pilsicainide in only the RVOT. The RTc was longer at baseline and increased by pilsicainide in only the RVOT. On the other hand, the QRS duration was slightly widened at baseline, further increased by pilsicainide, but not changed by isoproterenol in both leads. CONCLUSIONS: The ST-segment elevation and the RTc prolongation were localized and modulated by agents only in the RVOT region, while the slight QRS widening at baseline and further increase by pilsicainide were observed homogeneously. Our data suggest that depolarization abnormalities are distributed homogeneously, whereas repolarization abnormalities are localized in the RVOT.
机译：背景：已经在Brugada综合征中发现了钠通道基因SCN5A的突变，但尚不清楚钠通道功能障碍与心律失常的关系。我们通过使用87导联的体表电位图（BSPM）检查了Brugada综合征患者的复极化和复极化异常的空间分布。方法：在基线情况下和药理干预后，对28例Brugada综合征患者（男27例，49 +/- 14岁）进行BSPM记录。 QRS结束后20 ms的ST段幅度（ST20），QRS持续时间和校正的恢复时间（RTc）在所有87根导线中测量，并在反映右心室的6根导线（DF，5-6）中取平均值流出道（RVOT）电位和其他81引线。结果：仅在RVOT中，ST20在基线时升高，通过异丙肾上腺素标准化，在比索替尼中升高。 RTc在基线时较长，仅在RVOT中由比西卡胺增加。另一方面，QRS持续时间在基线时略有加宽，比尔斯卡尼德进一步增加，但两个引线中的异丙肾上腺素均未改变。结论：ST段抬高和RTc延长仅受RVOT区域内药物的局限和调节，而在基线时QRS略微加宽，比西卡尼特则进一步增加。我们的数据表明，去极化异常分布均匀，而去极化异常位于RVOT中。

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