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House musk shrew, Suncus murinus: A novel and natural obesity-resistant animal model

机译：麝香的家，Suncus murinus：一种新型的天然抗肥胖动物模型

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Background and aims: Obesity is the principal risk factor for metabolic syndrome. The establishment of an appropriate animal model is urgently required to elucidate the mechanisms of visceral fat accumulation, metabolic syndrome and to develop therapeutic strategies. In the present study, we investigated a novel and natural obesity-resistant animal model, the house musk shrew, Suncus murinus. Methods: Ten male Suncus murinus were employed to investigate the body weight, body mass index (BMI), and plasma glucose levels. Besides, five male Suncus murinus were employed to measure visceral fat accumulation by in vivo micro-computerized tomography (micro-CT) during gradual aging. Thirteen male Sprague-Dawley rats were employed as control animals (n=10, n=3, respectively). Results: Body weight hardly changed during aging from 2-month to 12-month-old, and less visceral fat accumulation, especially mesenteric fat accumulation, occurred until old age in Suncus murinus. BMI and micro-CT measurement showed the same results; the rate of visceral fat accumulation in 1-year-old shrews was only 2.93% and was considerable lower than in 1-year-old rats (36.03%). Conclusions: It was suggested that Suncus murinus is a suitable and efficacious model to investigate obesity and metabolic syndrome, particularly the mechanism of obesity resistance.
机译：背景与目的：肥胖是代谢综合征的主要危险因素。迫切需要建立适当的动物模型，以阐明内脏脂肪蓄积，代谢综合征和制定治疗策略。在本研究中，我们调查了一种新型且天然的抗肥胖动物模型，即家麝香，即鼠尾草。方法：采用十只雄性Suncus murinus来调查体重，体重指数（BMI）和血浆葡萄糖水平。此外，在逐渐衰老过程中，通过体内微机断层扫描（micro-CT），采用了五只雄性Suncus murinus来测量内脏脂肪积累。将13只雄性Sprague-Dawley大鼠用作对照动物（分别为n ＝ 10，n ＝ 3）。结果：从衰老的2个月到12个月，体重几乎没有变化，直到衰老，内脏脂肪的积累特别是肠系膜脂肪的积累减少。 BMI和micro-CT测量显示相同的结果。 1岁sh的内脏脂肪蓄积率仅为2.93％，远低于1岁鼠的36.03％。结论：有人认为Suncus murinus是研究肥胖和代谢综合症，特别是肥胖抵抗机制的合适且有效的模型。

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