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首页> 外文期刊>Obesity and metabolism >Effects of weight loss on metabolic control, blood pressure, carotid intima-media thickness and abdominal fat distribution in obese geriatric women
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Effects of weight loss on metabolic control, blood pressure, carotid intima-media thickness and abdominal fat distribution in obese geriatric women

机译：减肥对肥胖老年妇女代谢控制，血压，颈动脉内膜中层厚度和腹部脂肪分布的影响

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Background and aims: Obesity is a growing health concern worldwide. Few studies have examined the effects of weight loss on metabolic and cardiovascular risk factors in obese elderly. We, therefore, examined the effects of weight loss on metabolic and cardiovascular risk factors such as blood pressure, carotid intima-media thickness, and abdominal fat distribution in obese geriatric women. Methods: Thirteen obese women aged 66-83 years (mean age 71.2?9yrs) with a body mass index of 35.6-49 kg/m2 (mean body mass index 39.9?3 kg/m2) were evaluated. Only subjects with uncomplicated obesity were included. Anthropometric parameters, lipid levels, glycemic control, insulin sensitivity, homocysteine levels, blood pressure, carotid intima-media thickness and abdominal fat distribution were made before and after a 6-month Orlistatplus hypocaloric diet. Results: Subjects lost an average of8.4?2 kg (9.4%). Total cholesterol, hemoglobin Ale, fasting insulin, and insulin resistance decreased significantly, whereas other parameters including low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, triglyceride, and homocystein did not change after weight loss. In addition, substantial reductions of 24-hour ambulatory systolic and nighttime systolic blood pressures were observed at the end of the study, but not the diastolic blood pressure associated with weight loss. Both carotid intima-media thickness and abdominal fat thicknesses such as intra-abdominalfat and subcutaneous fat decreased significantly after weight loss. Conclusions: Moderate weight loss over 6 months in uncomplicated obese older women produced substantial improvements in the cholesterol levels, hemoglobin Ale, insulin resistance and other cardiovascular risk factors including blood pressure, carotid intima-media thickness and abdominal fat distribution.
机译：背景和目标：肥胖是全球范围内日益关注的健康问题。很少有研究检查体重减轻对肥胖老年人代谢和心血管危险因素的影响。因此，我们检查了减肥对肥胖老年妇女的代谢和心血管危险因素（如血压，颈动脉内膜中层厚度和腹部脂肪分布）的影响。方法：对13名66-83岁（平均年龄71.2至9岁），体重指数为35.6-49 kg / m2（平均体重指数39.9至3 kg / m2）的肥胖妇女进行了评估。仅包括单纯性肥胖的受试者。在六个月的Orlistatplus低热量饮食前后，测量人体测量学参数，血脂水平，血糖控制，胰岛素敏感性，高半胱氨酸水平，血压，颈动脉内膜中层厚度和腹部脂肪分布。结果：受试者平均损失了8.4？2 kg（9.4％）。总胆固醇，血红蛋白Ale，空腹胰岛素和胰岛素抵抗显着降低，而体重减轻后，其他参数包括低密度脂蛋白胆固醇，高密度脂蛋白胆固醇，极低密度脂蛋白胆固醇，甘油三酸酯和高半胱氨酸不变。此外，在研究结束时，观察到24小时动态收缩压和夜间收缩压显着降低，但与体重减轻相关的舒张压并未降低。减肥后，颈动脉内膜中层厚度和腹部脂肪厚度（如腹内脂肪和皮下脂肪）均显着降低。结论：在没有并发症的肥胖老年妇女中，六个月以上的中等体重减轻使胆固醇水平，血红蛋白Ale，胰岛素抵抗和其他心血管危险因素（包括血压，颈动脉内膜中层厚度和腹部脂肪分布）显着改善。

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