...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Obesity and metabolism >Visceral adiposity as a cause of some cardiovascular disorders. Old and new adipocytokines
【24h】

Visceral adiposity as a cause of some cardiovascular disorders. Old and new adipocytokines

机译：内脏脂肪引起某些心血管疾病。新旧脂肪细胞因子

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Visceral adiposity is often associated with significant cardiovascular morbidities and death. In fact, abdominal fat accumulation acts as an endocrine organ, by secreting a variety ofbioactive peptides, also called "adipocytokines", including Leptin, Adiponectin, Tumor Necrosis factor-a (TNF-a), Resistin, PAI-1, PPAR-yand Monobutirin. These peptides increase the risk of obesity-related cardiovascular disorders, by multiple mechanisms. Recently, a new adipocytokine, as Visfatin, was identified. It is expressed at many levels, favouring some cardiovascular derangements by pro-inflammatory and immunomodulating activities. In the latest years Apelin, a novel bioactive peptide, was isolated too. This acts on cardiovascular system, by decreasing blood pressure, increasing heart rate and exerting positive inotropic effect on the cardiac muscle. Subsequently, two other adipocytokines, Retinol-Binding Protein 4 and Lipocalin-2 (deriving from Lipocalin's family) are isolated by visceral adipose tissue (VAT). Also these Lipocalin-derived members are associated with atherosclerotic process, systemic hypertension and coronary disease. In addition Vaspin, a novel adipocytokine expressed by VAT, recently was found to be related to insulin sensitivity, obesity and microcirculation derangement. In most recent years, Omentin-1 was found inversely related to insulin resistance, and polycystic ovary syndrome in overweight women. In conclusion, white adipocytes secrete some peptides binded to the visceral fat accumulation. These act on cardiovascular system, by causing accelerated atherosclerosis, systemic hypertension, insulin resistance and favouring some vascular processess, such as inflammation, vasoconstriction and thrombosis. Probably, new adipocytokines will be isolated, able to further elucidate the aetiology of most of cardiovascular disorders, usually present in individuals with abdominal fat accumulation.
机译：内脏肥胖通常与明显的心血管疾病和死亡有关。实际上，腹部脂肪积聚通过分泌多种生物活性肽（也称为“脂肪细胞因子”）而充当内分泌器官，包括瘦素，脂联素，肿瘤坏死因子-a（TNF-a），抵抗素，PAI-1，PPAR-y和单丁丁灵。这些肽通过多种机制增加了与肥胖相关的心血管疾病的风险。最近，鉴定了一种新的脂肪细胞因子Visfatin。它以多种水平表达，通过促炎和免疫调节活性促进某些心血管紊乱。在最近几年，也分离出了一种新型的生物活性肽Apelin。它通过降低血压，增加心率和对心肌产生正性肌力作用来作用于心血管系统。随后，通过内脏脂肪组织（VAT）分离了另外两种脂肪细胞因子，视黄醇结合蛋白4和Lipocalin-2（来自Lipocalin家族）。这些脂质脂蛋白衍生的成员也与动脉粥样硬化过程，系统性高血压和冠状动脉疾病有关。另外，最近发现Vaspin是一种由VAT表达的新型脂肪细胞因子，与胰岛素敏感性，肥胖症和微循环紊乱有关。在最近几年中，发现Omentin-1与超重女性的胰岛素抵抗和多囊卵巢综合征呈负相关。总之，白色脂肪细胞分泌一些与内脏脂肪积累结合的肽。它们通过引起加速的动脉粥样硬化，全身性高血压，胰岛素抵抗并促进某些血管进程如炎症，血管收缩和血栓形成而作用于心血管系统。可能会分离出新的脂肪细胞因子，从而能够进一步阐明大多数心血管疾病的病因，这些疾病通常存在于腹部脂肪积聚的个体中。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号