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首页> 外文期刊>Cell biology international. >Anti-apoptotic activity of Bak Foong Pills and its ingredients on 6-hydroxydopamine-induced neurotoxicity in PC12 cells.
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Anti-apoptotic activity of Bak Foong Pills and its ingredients on 6-hydroxydopamine-induced neurotoxicity in PC12 cells.

机译：白凤丸及其成分对6-羟基多巴胺诱导的PC12细胞神经毒性的抗凋亡活性。

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摘要

Bak Foong Pills (BFP), a traditional Chinese medicine used for centuries for the enhancement of women's health, was shown to display neuro-protective activity in the 1-methyl-4-phenyl-1,2,4,6,-tetrahydro-pyridine (MPTP)-induced mouse model in a previous study. In order to elucidate its mechanism of action, we investigated the anti-apoptotic properties of Bak Foong Pills and its main ingredients, including Panax ginseng, Angelica sinensis, Glycyrrhiza uralensis, and Ligusticum chuanxiong, in the 6-hydroxydopamine (6-OHDA)-treated PC12 cell model. The addition of the neurotoxin could cause significant cell death and reduction of cell proliferation, as shown in the results determined by MTT assay, nitric oxide (NO) measurement and flow cytometric propidium iodine (PI) staining analysis, while pre-treatment of PC12 cell with either BFP or its main ingredients prevented the toxicity to some degree. In addition, the neurotoxin caused an elevated activation of caspase-3, the key enzyme for activation of the cellular apoptotic cascade, whereas BFP or its main ingredients inhibited the activation of caspase-3. These results strongly indicate that BFP and its main ingredients may provide a useful therapeutic strategy for the treatment of neurodegenerative diseases, such as Parkinson's disease.
机译：百年来，Bak Foong药丸（BFP）可以改善妇女的健康状况，它在1-甲基-4-苯基-1,2,4,6，-四氢-吡啶（MPTP）诱导的小鼠模型在先前的研究中。为了阐明其作用机理，我们研究了6-羟基多巴胺（6-OHDA）-中的白凤丸及其主要成分（人参，当归，甘草和川gust）的抗凋亡特性。处理过的PC12细胞模型。如通过MTT分析，一氧化氮（NO）测量和流式细胞术碘化丙啶（PI）染色分析所确定的结果所示，同时对PC12细胞进行预处理，发现神经毒素的添加可能导致明显的细胞死亡并减少细胞增殖。与BFP或其主要成分配合使用可在一定程度上防止毒性。另外，神经毒素引起激活细胞凋亡级联反应的关键酶caspase-3的活化，而BFP或其主要成分抑制caspase-3的活化。这些结果强烈表明，BFP及其主要成分可能为神经退行性疾病（如帕金森氏病）的治疗提供有用的治疗策略。

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