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首页> 外文期刊>Cell biology international. >Apoptosis effects of Xrel3 c-Rel/Nuclear Factor-kappa B homolog in human cervical cancer cells.
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Apoptosis effects of Xrel3 c-Rel/Nuclear Factor-kappa B homolog in human cervical cancer cells.

机译：Xrel3 c-Rel /核因子-κB同源物在人宫颈癌细胞中的凋亡作用。

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摘要

Cervical cancer is considered a common yet preventable cause of death in women. In this report, we studied the role of the NF-kappaB gene family in HeLa human cervical cancer cells, using the Xrel3 c-Rel homologue of Xenopus laevis. The expression of Xrel3/c-Rel slowed cell growth 6-fold, consistent with an upregulated expression of the cell cycle inhibitor p21. The activated PARP apoptosis effector was significantly increased (P<0.01). Based on cell viability assays Xrel3 provided an anti-apoptotic effect in 1 muM cisplatin, and this was associated with significantly lower levels of the apoptotic proteins Bax and MDM-2 (P<0.05). Furthermore, there was a 3-fold drop in the level of the tumor suppressor protein p53. In 5 muM cisplatin, expression of HeLa Xrel3 enhanced apoptosis by significantly increasing the expression of the apoptotic proteins Bax and MDM-2 (P<0.05). However, the tumor suppressor protein p53 showed a significant decrease (P<0.05) relative to the control. Thus, c-Rel/NF-kappaB may potentially be of clinical significance, especially in tumors exhibiting resistance to high-level chemotherapy.
机译：宫颈癌被认为是女性常见但可预防的死亡原因。在此报告中，我们使用非洲爪蟾的Xrel3 c-Rel同源物研究了NF-kappaB基因家族在HeLa人宫颈癌细胞中的作用。 Xrel3 / c-Rel的表达使细胞生长减慢了6倍，这与细胞周期抑制剂p21的表达上调一致。活化的PARP凋亡效应子显着增加（P <0.01）。基于细胞活力测定，Xrel3在1μM顺铂中具有抗凋亡作用，这与凋亡蛋白Bax和MDM-2的水平显着降低有关（P <0.05）。此外，肿瘤抑制蛋白p53的水平下降了3倍。在5μM顺铂中，HeLa Xrel3的表达通过显着增加凋亡蛋白Bax和MDM-2的表达来增强细胞凋亡（P <0.05）。然而，相对于对照，抑癌蛋白p53显示出显着降低（P ＜0.05）。因此，c-Rel / NF-kappaB可能具有临床意义，尤其是在对高水平化学疗法产生抗性的肿瘤中。

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