Effects of ATRA on expression of mRNA binding protein p62 in human gastric cancer cells.

Shi P; Huang Z; Wang S; Zhang J; Peng X

首页> 外文期刊>Cell biology international. >Effects of ATRA on expression of mRNA binding protein p62 in human gastric cancer cells.

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Effects of ATRA on expression of mRNA binding protein p62 in human gastric cancer cells.

机译：ATRA对人胃癌细胞中mRNA结合蛋白p62表达的影响。

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The distribution of the cancer-associated protein p62 in human gastric carcinoma (BGC-823) cells was examined by confocal laser scanning microscopy and electron microscope immunocytochemistry. In control cells p62 was cytoplasmic in location and concentrated in the cytoplasmic matrix, but when cell growth was inhibited by treatment with 50 microM all-trans-retinoic acid (ATRA) for 5 days, p62 expression decreased and the protein was translocated from cytoplasm to nucleus. Ultrastructural localization using gold particles showed that p62 was bond mainly to a linear structure in nucleus. The speculation that p62 binds Insulin-like growth factor (IGF)-II mRNA indicates its probable involvement in the posttranscriptional IGF-II mRNA processing and p62 could play a role in tumorgenesis by regulating the expression of IGF-II. Further studies will be needed to confirm this view.

机译：通过共聚焦激光扫描显微镜和电子显微镜免疫细胞化学检查了癌相关蛋白p62在人胃癌（BGC-823）细胞中的分布。在对照细胞中，p62在细胞质中定位并集中在细胞质基质中，但是当用50 microM全反式维甲酸（ATRA）处理5天抑制细胞生长时，p62的表达下降，蛋白质从细胞质转移到细胞质中。核。使用金颗粒的超微结构定位表明，p62主要与原子核中的线性结构键合。 p62结合胰岛素样生长因子（IGF）-II mRNA的推测表明其可能参与了转录后IGF-II mRNA的加工，p62可能通过调节IGF-II的表达在肿瘤发生中发挥作用。需要进一步的研究来确认这一观点。

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《Cell biology international.》 |2005年第2期|共5页
作者
Shi P; Huang Z; Wang S; Zhang J; Peng X;
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正文语种 eng
中图分类细胞生物学;
关键词
Carcinoma; RNA-Binding Proteins; Stomach Neoplasms; Tretinoin; 癌; RNA结合蛋白质类; 胃肿瘤; 维甲酸;

机译：Carcinoma;RNA-Binding Proteins;Stomach Neoplasms;Tretinoin;癌;RNA结合蛋白质类;胃肿瘤;维甲酸;

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1. Effects of ATRA on expression of mRNA binding protein p62 in human gastric cancer cells. [J] . Shi P, Huang Z, Wang S, Cell biology international. . 2005,第2期

机译：ATRA对人胃癌细胞中mRNA结合蛋白p62表达的影响。
2. Overexpression of IGF2 mRNA-Binding Protein 2 (IMP2/p62) as a Feature of Basal-like Breast Cancer Correlates with Short Survival [J] . Barghash A., Helms V., Kessler S. M. Scandinavian journal of immunology. . 2015,第2期

机译：作为基底样乳腺癌特征的IGF2 mRNA结合蛋白2（IMP2 / p62）的过表达与生存期短相关。
3. Humoral autoimmune response to IGF2 mRNA-Binding protein (IMP2/p62) and its tissue-specific expression in colon cancer [J] . LiuW., LiZ., XuW., Scandinavian journal of immunology. . 2013,第4期

机译：结肠癌对IGF2 mRNA结合蛋白（IMP2 / p62）的体液自身免疫反应及其组织特异性表达
4. Effects of Bcl-2, bax and p53 Gene Protein Expressions in Gastric Cancer Tissue on the Apoptosis of Cancer Cells [C] . Lei Zhang, Dapeng Li, Guannan Lu International Conference on Applied Mechanics, Materials and Manufacturing . 2013

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5. The effects of poly (A) -binding protein 1 (PABP1) over-expression on mRNA metabolism and the regulation of PABP1 expression following recovery from heat shock [D] . Ma, Shuhua 2008

机译：从热休克恢复后，聚（A）结合蛋白1（PABP1）的过表达对mRNA代谢和PABP1表达调节的影响
6. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. [O] . I Shimomura, H Shimano, J D Horton, 1997

机译：人和小鼠器官及培养细胞中固醇调节元件结合蛋白-1 mRNA中外显子1a和1c的差异表达。
7. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. [O] . Shimomura, I, Shimano, H, Horton, J D, 1997

机译：人和小鼠器官及培养细胞中固醇调节元件结合蛋白-1 mRNA中外显子1a和1c的差异表达。

Effects of ATRA on expression of mRNA binding protein p62 in human gastric cancer cells.

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