Osteocalcin is angiogenic in vivo.

Cantatore FP; Crivellato E; Nico B; Ribatti D

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Osteocalcin is angiogenic in vivo.

机译：骨钙素在体内具有血管生成作用。

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The exact function of osteocalcin (OC), a protein synthesized by osteoblasts during the matrix mineralization phase, is still unknown. In this study we investigated the capacity of OC to promote vasoproliferation in chick embryo chorioallantoic membrane (CAM), a well established in vivo assay for angiogenesis and anti-angiogenesis. The results showed that OC stimulates angiogenesis and that the response is similar to that obtained with FGF-2, a well-known angiogenic cytokine. It has previously been demonstrated that OC is involved in bone repair, so the angiogenic activity reported here might also play a crucial role in bone formation.

机译：骨钙蛋白（OC）是成骨细胞在基质矿化阶段合成的蛋白质的确切功能仍然未知。在这项研究中，我们调查了OC促进鸡胚绒膜尿囊膜（CAM）中血管增殖的能力，这是一种成熟的体内血管生成和抗血管生成测定方法。结果表明，OC刺激血管生成，并且其响应类似于使用众所周知的血管生成细胞因子FGF-2所获得的响应。先前已证明OC参与骨修复，因此此处报道的血管生成活性可能也对骨形成起关键作用。

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《Cell biology international.》 |2005年第7期|共3页
作者
Cantatore FP; Crivellato E; Nico B; Ribatti D;
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正文语种 eng
中图分类细胞生物学;
关键词
degrees C; in vivo; angiogenesis; Osteocalcin Assay; Skeletal bone;

机译：℃;体内;血管生成;骨钙素测定;骨骼;

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1. Osteocalcin is angiogenic in vivo. [J] . Cantatore FP, Crivellato E, Nico B, Cell biology international. . 2005,第7期

机译：骨钙素在体内具有血管生成作用。
2. GPRC6A mediates responses to osteocalcin in beta-cells in vitro and pancreas in vivo. [J] . Pi M, Wu Y, Quarles LD Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research . 2011,第7期

机译：GPRC6A介导体外和体内胰腺细胞对骨钙素的反应。
3. Chromatin hyperacetylation abrogates vitamin D-mediated transcriptional upregulation of the tissue-specific osteocalcin gene in vivo. [J] . Montecino M, Frenkel B, van Wijnen-AJ, Biochemistry . 1999,第4期

机译：染色质过度乙酰化消除了体内组织特异性骨钙素基因的维生素D介导的转录上调。
4. Integration of Cysteine-rich angiogenic inducer 61 (CYR61) into collagen biomaterial promotes the therapeutic potential of circulating angiogenic cells [C] . Brian McNeill, Branka Vulesevic, Marc Ruel, Society for Biomaterials annual meeting and exposition . 2013

机译：将富含半胱氨酸的血管生成诱导剂61（CYR61）整合到胶原生物材料中可促进循环血管生成细胞的治疗潜力
5. The Anti-tumor and Anti-angiogenic Effects of Photodynamic Therapy with Pheophorbide a on Breast Cancer in vitro and in vivo. [D] . Hoi, Wan Heng. 2011

机译：磷脂酰磷光动力疗法在体外和体内对乳腺癌的抗肿瘤和抗血管生成作用。
6. Correction to: Foy KC Miller MJ Moldovan N Carson III WE Kaumaya PTP. Combined vaccination with HER-2 peptide followed by therapy with VEGF peptide mimics exerts effective anti-tumor and anti-angiogenic effects in vitro and in vivo. OncoImmunology 2012; 1:1048–1060 [O] . Kevin C. Foy, Megan J. Miller, Nicanor Moldovan, 2013

机译：更正为：Foy KCMiller MJMoldovan NCarson III WEKaumaya PTP。 HER-2肽的联合疫苗接种然后用VEGF肽模拟物进行治疗在体内外均发挥有效的抗肿瘤和抗血管生成作用。肿瘤免疫学2012; 1：1048–1060
7. Synthetic Site-Selectively Mono-6-O-Sulfated Heparan Sulfate Dodecasaccharide Shows Anti-Angiogenic Properties In Vitro and Sensitizes Tumors to Cisplatin In Vivo. [O] . Avizienyte, Egle, Cole, Claire, Rushton, Graham, 2016

机译：合成位点 - 选择性单-6-O-硫酸化硫酸乙酰肝素十二糖在体外显示抗血管生成特性并使肿瘤对顺铂的体内敏感。

Osteocalcin is angiogenic in vivo.

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