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首页> 外文期刊>Cell biology international. >Whole-genome chromosome distribution during nuclear fragmentation of giant trophoblast cells of Microtus rossiaemeridionalis studied with the use of gonosomal chromatin arrangement.
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Whole-genome chromosome distribution during nuclear fragmentation of giant trophoblast cells of Microtus rossiaemeridionalis studied with the use of gonosomal chromatin arrangement.

机译：利用淋巴小体染色质排列研究了俄罗斯蔷薇（Microtus rossiaemeridionalis）巨大滋养层细胞核分裂过程中的全基因组染色体分布。

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摘要

Gonosomal chromatin bodies (GCBs), i.e. blocks of condensed chromatin consisting of heterochromatized region of the sex chromosomes of the field vole M. rossiaemeridionalis, were used as a natural interphase chromosome marker in order to clarify the regularities of GCB rearrangement during nuclear fragmentation of secondary giant trophoblast cells (SGTCs) at the end of their differentiation. Cytophotometrical measurements of DNA content in the nuclei, nuclear fragments and simultaneously in the GCBs were made in the secondary giant SGTCs of field vole M. rossiaemeridionalis. In most cases 1 to 2 GCBs get into the nuclear fragments at different ploidy levels. In the nuclear fragments, GCB DNA content decreased mostly proportionally to DNA content in the whole fragments corresponding to 2c, 4c and 8c. The data obtained demonstrate a regular whole-genome chromosome distribution into nuclear fragments. A possible mechanism of nuclear fragmentation that largely ensures a balanced genome in nuclear fragmentsis discussed.
机译：角质染色质体（GCBs），即由田鼠rossiaemeridionalis田鼠的性染色体的异染色体区域组成的浓缩染色质块，被用作天然的中间相染色体标记，以阐明继发性核分裂过程中GCB重排的规律性分化结束时出现巨大的滋养层细胞（SGTC）。在田鼠蔷薇分枝杆菌的次级巨型SGTC中，进行了光度法测量细胞核，核碎片以及GCB中DNA的含量。在大多数情况下，有1至2个GCB以不同的倍性水平进入核片段。在核片段中，GCB DNA含量与与2c，4c和8c对应的整个片段中的DNA含量成比例下降。获得的数据表明，整个基因组的染色体分布规则成核片段。讨论了可能在很大程度上确保核片段中基因组平衡的核片段化机理。

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