Adhesiveness of beta5 integrin variant lacking FNK767-769 is similar to that of the prototype containing FNKFNK764-769.

Kawahara E; Saito A; Kobayashi J; Maenaka S; Minamoto T; Imai MA; Oda Y

首页> 外文期刊>Cell biology international. >Adhesiveness of beta5 integrin variant lacking FNK767-769 is similar to that of the prototype containing FNKFNK764-769.

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Adhesiveness of beta5 integrin variant lacking FNK767-769 is similar to that of the prototype containing FNKFNK764-769.

机译：缺少FNK767-769的beta5整联蛋白变体的粘附力类似于包含FNKFNK764-769的原型的粘附力。

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Little is known about the functions of two different beta5 integrins: repeated-FNK (FNKFNK764-769) and single-FNK (FNK764-766) amino acid sequences in the cytoplasmic domain. We examined whether they occurred as germ line mutations or somatic mutations associated with neoplastic transformation, and whether there were functional alterations. Out of six cultured cell lines, only KATO-III cells had the single-FNK beta5 sequence. The single-FNK beta5 was found in 9 out of 79 patients with colon carcinoma, but no somatic mutations were detected in cancerous tissues. CHO cells were transformed with expression vectors containing single-FNK or repeated-FNK beta5 cDNA, which were derived from KATO-III cells. CHO cells transfected with single-FNK and repeated-FNK showed similar adhesiveness to, and proliferative activity on, vitronectin substrates.

机译：对于两种不同的β5整联蛋白的功能，人们所知甚少：胞质结构域中的重复FNK（FNKFNK764-769）和单FNK（FNK764-766）氨基酸序列。我们检查了它们是否是与肿瘤转化相关的种系突变或体细胞突变，以及是否存在功能改变。在六个培养的细胞系中，只有KATO-III细胞具有单个FNK beta5序列。在79例结肠癌患者中有9例发现了单FNK beta5，但在癌组织中未检测到体细胞突变。使用含有单个FNK或重复FNK beta5 cDNA的表达载体转化CHO细胞，该表达载体来自KATO-III细胞。用单FNK和重复FNK转染的CHO细胞显示与玻连蛋白底物相似的粘附性和增殖活性。

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《Cell biology international.》 |2005年第7期|共8页
作者
Kawahara E; Saito A; Kobayashi J; Maenaka S; Minamoto T; Imai MA; Oda Y;
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正文语种 eng
中图分类细胞生物学;
关键词
Unmarried; integrin beta5; Mutation; somatic; CHO Cells; CHO细胞;

机译：Unmarried;integrin beta5;Mutation;somatic;CHO Cells;CHO细胞;

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1. Adhesiveness of beta5 integrin variant lacking FNK767-769 is similar to that of the prototype containing FNKFNK764-769. [J] . Kawahara E, Saito A, Kobayashi J, Cell biology international. . 2005,第7期

机译：缺少FNK767-769的beta5整联蛋白变体的粘附力类似于包含FNKFNK764-769的原型的粘附力。
2. Mice Lacking the Integrin beta5 Subunit Have Accelerated Osteoclast Maturation and Increased Activity in the Estrogen-Deficient State. [J] . Lane NE, Yao W, Nakamura MC, Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research . 2005,第1期

机译：缺少整合素β5亚基的小鼠在雌激素缺乏状态下加速了破骨细胞的成熟并增加了活性。
3. beta5 integrin is the major contributor to the alphaVintegrin-mediated blockade of HIV-1 replication. [J] . Ballana E, Pauls E, Clotet B, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2011,第1期

机译：beta5整合素是alphaVintegrin介导的HIV-1复制阻断的主要贡献者。
4. An autoimmune disease-associated CTLA4 splice variant lacking the B7 binding domain signals negatively in T cells [C] . Lalitha Vijayakrishnan, Jacqueline M. Slavik, Zsolt Illes, Symposium on Genetics of Autoimmunity . 2005

机译：一种自身免疫疾病相关的CTLA4接头变体缺乏B7结合域在T细胞中产生负面信号
5. Integrin Splice Variant β4e: Characterization of a Novel Membrane Receptor in Epithelial Cancers [D] . McGrath, Julie. 2020

机译：整合素剪接变体β4e：上皮癌中新型膜受体的表征
6. Regulation of cellular interactions with laminin by integrin cytoplasmic domains: the A and B structural variants of the alpha 6 beta 1 integrin differentially modulate the adhesive strength morphology and migration of macrophages. [O] . L M Shaw, A M Mercurio 1994

机译：整联蛋白胞质结构域与层粘连蛋白的细胞相互作用的调节：α6 beta 1整联蛋白的A和B结构变体差异地调节巨噬细胞的粘附强度形态和迁移。
7. Adhesiveness of β5 integrin variant lacking FNK767–769 is similar to that of the prototype containing FNKFNK764–769 [O] . Kawahara, Ei, Saito, Ayumi, Kobayashi, Jun, 2005

机译：缺乏FNK767-769的β5整合素变体的粘附性与含有FNKFNK764-769的原型相似
8. First Description of a Variant of E. Coli Lacking Superoxide Dismutase Activity Yet Able to Grow Efficiently on Minimal, Oxygenated Medium [R] . Fee, J. A. , Niederhoffer, E. C. , Naranjo, C. 1987

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Adhesiveness of beta5 integrin variant lacking FNK767-769 is similar to that of the prototype containing FNKFNK764-769.

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