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首页> 外文期刊>Cell biology international. >High expression of the taurine transporter TauT in primary cilia of NIH3T3 fibroblasts.
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High expression of the taurine transporter TauT in primary cilia of NIH3T3 fibroblasts.

机译：牛磺酸转运蛋白TauT在NIH3T3成纤维细胞的初级纤毛中的高表达。

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摘要

Taurine, present in high concentrations in various mammalian cells, is essential for regulation of cell volume, cellular oxidative status as well as the cellular Ca2+ homeostasis. Cellular taurine content is a balance between active uptake through the saturable, Na(+)-dependent taurine transporter TauT, and passive release via a volume-sensitive leak pathway. Here we demonstrate that: (i) TauT localizes to the primary cilium of growth-arrested NIH3T3 fibroblasts, (ii) long-term exposure to TNF(alpha) or hypertonic sucrose medium, i.e., growth medium supplemented with 100 mM sucrose, increases ciliary TauT expression and (iii) long-term exposure to hypertonic taurine medium, i.e., growth medium supplemented with 100 mM taurine, reduces ciliary TauT expression. These results point to an important role of taurine in the regulation of physiological processes located to the primary cilium.
机译：牛磺酸以高浓度存在于各种哺乳动物细胞中，对于调节细胞体积，细胞氧化状态以及细胞Ca2 +稳态至关重要。细胞牛磺酸含量是通过饱和的Na（+）依赖性牛磺酸转运蛋白TauT主动摄取与通过体积敏感泄漏途径被动释放之间的平衡。在这里，我们证明：（i）TauT定位于生长停滞的NIH3T3成纤维细胞的初级纤毛，（ii）长期暴露于TNFα或高渗蔗糖培养基，即补充有100 mM蔗糖的生长培养基，会增加纤毛TauT表达和（iii）长期暴露于高渗牛磺酸培养基（即补充有100 mM牛磺酸的生长培养基）会降低睫状TauT表达。这些结果表明牛磺酸在调节位于初级纤毛的生理过程中的重要作用。

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