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首页> 外文期刊>Cell biology international. >Ultrastructural alterations in ciliated protozoa under heavy metal exposure.
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Ultrastructural alterations in ciliated protozoa under heavy metal exposure.

机译：重金属暴露下纤毛原生动物的超微结构改变。

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摘要

Transmission electron microscopy was used to study the ultrastructural changes induced by exposure to Cd or Zn in three species of ciliated protozoa: Colpoda steinii, Cyrtolophosis elongata and Drepanomonas revoluta. The main cytoplasmic alterations were partial mitochondrial degeneration, cytoplasmic vacuolisation, accumulation of membranous debris and autophagosome formation. At the nuclear level we detected nucleolar fusion in the macronucleus, and micronuclear membrane modifications. We compared these modifications with those coinciding with ciliate encystment (a differentiation process induced by environmental nutritional stress) and with changes in eukaryotic cells treated with staurosporine, a potent protein kinase inhibitor considered to be an apoptosis inducer. Exposure to heavy metals also coincided with the appearance of electron-dense accumulations in the cytoplasm, which might be related to metallothionein-mediated detoxification. The results are compared with previously reported data fromciliates and microalgae treated with heavy metals.
机译：透射电子显微镜用于研究三种纤毛原生动物：Colpoda steinii，Cyrtolophosis elongata和Drepanomonas revoluta暴露于Cd或Zn引起的超微结构变化。主要的细胞质改变是线粒体部分变性，细胞质空泡化，膜碎片的积累和自噬体的形成。在核水平，我们检测到大核中的核仁融合和微核膜修饰。我们将这些修饰与纤毛囊化（环境营养胁迫诱导的分化过程）以及用星形孢菌素（一种被认为是凋亡诱导剂的有效蛋白激酶抑制剂）处理的真核细胞的变化相吻合。重金属的暴露也与细胞质中电子密集积累的出现相吻合，这可能与金属硫蛋白介导的排毒有关。将结果与先前报道的纤毛虫和重金属处理过的微藻的数据进行比较。

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