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首页> 外文期刊>Cell biology international. >EFFECT OF MICROTUBULE-SPECIFIC DRUGS UPON SPATIAL ORGANIZATION OF EXTRACELLULAR MATRIX IN FIBROBLASTIC CULTURES
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EFFECT OF MICROTUBULE-SPECIFIC DRUGS UPON SPATIAL ORGANIZATION OF EXTRACELLULAR MATRIX IN FIBROBLASTIC CULTURES

机译：微管特定药物对成纤维细胞外基质矩阵空间组织的影响

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摘要

The aim of this investigation was to study the effects of microtubule-specific digs, taxol and colcemid, on the distribution of cell-associated extracellular matrix in dense cultures of fibroblasts. Immunomorphological examination of human seven-day cultures revealed a dense network of fibronectin and tenascin matrix filaments preferentially oriented in parallel with the long axes of cell bodies. Depolymerization of the microtubular system by colcemid and its disorganization by taxol led to rapid and drastic changes in the organization of matrix network: fibronectin and tenascin filaments became disordered and, in particular, lost any orientation. These data show that the microtubular system controls the morphological organization, not only of intracellular cytoskeletal systems, but also of extracellular matrix structures.
机译：这项研究的目的是研究微管特异的挖掘物，紫杉醇和秋水仙胶对成纤维细胞密集培养中细胞相关细胞外基质分布的影响。对人类7天培养物的免疫形态学检查显示，纤连蛋白和腱生蛋白基质细丝的致密网络优选平行于细胞体的长轴取向。秋水仙胶对微管系统的解聚以及紫杉醇的解聚导致基质网络结构的迅速而剧烈的变化：纤连蛋白和腱生蛋白丝变得无序，特别是失去了取向。这些数据表明，微管系统不仅控制细胞内细胞骨架系统的形态组织，而且还控制细胞外基质结构的形态组织。

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