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首页> 外文期刊>Cell biology international. >ROLE OF FEEDER CELLS IN SPREADING AND CYTOSKELETON ORGANIZATION OF NEWBORN RAT KERATINOCYTES
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ROLE OF FEEDER CELLS IN SPREADING AND CYTOSKELETON ORGANIZATION OF NEWBORN RAT KERATINOCYTES

机译：饲料细胞在新生大鼠角质形成细胞扩散和细胞骨架组织中的作用。

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摘要

We studied the effect of feeder cells (fibroblasts) and a mixture of the extracellular matrix components, Matrigel, on spreading and cytoskeleton organization of newborn rat keratinocytes (REK). REK formed lamellipodia on being plated together with feeder cells and on the Matrigel as a substrate whereas the same REK plated alone on a plastic surface formed filopodia. REK lamellipodia formation in co-cultures depended on the fibroblast addition time. Although conditioned medium from fibroblast cultures was not enough to induce lamellipodia, the extracellular matrix left after fibroblast removal was as effective as Matrigel. Our results indicate that lamellipodia formation seems to depend on the factor(s) secreted by fibroblasts and associated with the extracellular matrix.
机译：我们研究了饲养细胞（成纤维细胞）和细胞外基质成分Matrigel混合物对新生大鼠角质形成细胞（REK）扩散和细胞骨架组织的影响。 REK与供体细胞一起铺板并在Matrigel上作为底物形成了片状脂网，而同一REK单独铺在塑料表面上则形成了丝状伪足。共培养中REK片状脂蛋白的形成取决于成纤维细胞的添加时间。尽管来自成纤维细胞培养物的条件培养基不足以诱导片状脂溢，但去除成纤维细胞后残留的细胞外基质与基质胶一样有效。我们的结果表明，片状脂蛋白的形成似乎取决于成纤维细胞分泌并与细胞外基质相关的因子。

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