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首页> 外文期刊>Cell biology international. >DISTRIBUTION OF ACETYLATED TUBULIN IN CULTURED CELLS AND TISSUES FROM THE ATLANTIC COD (GADUS MORHUA) - ROLE OF ACETYLATION IN COLD ADAPTATION AND DRUG STABILITY
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DISTRIBUTION OF ACETYLATED TUBULIN IN CULTURED CELLS AND TISSUES FROM THE ATLANTIC COD (GADUS MORHUA) - ROLE OF ACETYLATION IN COLD ADAPTATION AND DRUG STABILITY

机译：乙酰化微管蛋白在大西洋鳕鱼（GADUS MORHUA）的培养细胞和组织中的分布-乙酰化在冷适应和药物稳定性中的作用

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摘要

The Atlantic cod (Gadus morhua) is a poikilothermic animal living at temperatures between 2-15 degrees C. Isolated cod brain tubulin is, in contrast to mammalian brain tubulin, posttranslationally modified by acetylation to a high extent. To investigate the role of acetylation in cold adaptation, microtubules were isolated by a taxol-dependent procedure from different organs of the cod, and cells from different tissues were cultured. All cells from skin and brain were able to grow between 4 degrees C and room temperature. Microtubules in the cultured cells were sometimes severed near the periphery of the cells. Microtubules in brain cells were in general more stable to vinblastine and colchicine, when compared to skin cells. Acetylated microtubules were found only in brain cells, in peripheral nerves on scales and in nerves of the intestinal tract and in microtubules isolated from neuronal tissue. Our results show that acetylated microtubules are found both in the central and peripheral nervous system, but that there is no correlation between acetylation and cold-adaptation.
机译：大西洋鳕鱼（Gadus morhua）是一种温度过高的动物，生活在2-15摄氏度之间。与哺乳动物脑微管蛋白相反，分离的鳕鱼脑微管蛋白在很大程度上被乙酰化后翻译。为了研究乙酰化在冷适应中的作用，通过紫杉醇依赖性方法从鳕鱼的不同器官中分离了微管，并培养了来自不同组织的细胞。来自皮肤和大脑的所有细胞都能够在4摄氏度至室温之间生长。培养细胞中的微管有时在细胞外围附近被切断。与皮肤细胞相比，脑细胞中的微管通常对长春碱和秋水仙碱更稳定。乙酰化的微管仅存在于脑细胞，鳞状神经和肠道神经中以及从神经元组织分离的微管中。我们的结果表明，在中枢神经系统和周围神经系统中都发现了乙酰化的微管，但是乙酰化和冷适应之间没有关联。

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