NGF - NOT JUST FOR NEURONS [Review]

Scully JL; Otten U

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NGF - NOT JUST FOR NEURONS [Review]

机译：NGF-不仅仅是神经元[评论]

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Nerve growth factor (NFF) is the prototypic member of-a family of related neurotrophins (Nts). Although originally defined by its actions in the peripheral and central nervous systems, recent data indicate the presence of extensive interactions between NGF and the endocrine and immune systems steroid hormones are able to modulate the neurosomal expression of NGF, while functional NGF receptors have been detected on cells of the immune system, and increased levels of NGF protein are found during the acute phase of diseases with a significant inflammatory component. These wider functions are likely to be of concern in any attempted therapeutic use of NGF.

机译：神经生长因子（NFF）是相关神经营养蛋白（Nts）家族的原型成员。尽管最初由其在周围和中枢神经系统中的作用定义，但最近的数据表明，NGF与内分泌和免疫系统之间存在广泛的相互作用，类固醇激素能够调节NGF的神经体表达，而在其上已检测到功能性NGF受体。在具有显着炎症成分的疾病的急性期发现免疫系统细胞和NGF蛋白水平升高。这些较广泛的功能可能在NGF的任何尝试性治疗用途中引起关注。

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《Cell biology international.》 |1995年第5期|共11页
作者
Scully JL; Otten U;
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正文语种 eng
中图分类细胞生物学;
关键词
Nerve growth factor; Choline acetyltransferase activity; Pituitary adrenocortical axis; Ciliary neurotrophic factor; Messenger rna expression; Peritoneal mast cells; Human lymphocytes b; Rat sciatic nerve; Factor receptor; Trk protooncogene;

机译：神经生长因子;胆碱乙酰转移酶活性;垂体肾上腺皮质轴;睫状神经营养因子;Messenger rna表达;腹膜肥大细胞;人类淋巴细胞b;大鼠坐骨神经;因子受体;Trk原癌基因;

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专利

1. Ectopic trkA expression mediates a NGF survival response in NGF-independent sensory neurons but not in parasympathetic neurons. [J] . T E Allsopp, M Robinson, S Wyatt, Journal of cell biology . 1993,第6期

机译：异位trkA表达介导NGF依赖的感觉神经元中的NGF存活反应，但在副交感神经元中不介导。
2. NGF - NOT JUST FOR NEURONS [Review] [J] . Scully JL, Otten U Cell biology international. . 1995,第5期

机译：NGF-不仅仅是神经元[评论]
3. Short‐term swimming exercise attenuates the sensitization of dorsal horn neurons in rats with NGF NGF ‐induced low back pain [J] . Azambuja G., Hortscht U., Hoheisel U., European journal of pain : . 2018,第8期

机译：短期游泳运动减轻了NGF NGF大鼠背角神经元的敏化 - 屈服低腰疼
4. A PROPOSAL OF NEURON MODEL CAPABLE OF NEURITE ELONGATION BY NGF BASED ON PHYSIOLOGICAL CHARACTERISTICS [C] . Makoto Kikuchi Modelling, identification, and control . 2010

机译：基于生理学特征的NGF可延展神经元的神经元模型的建议
5. Functional roles of local and retrograde NGF-TrkA signaling in sympathetic neurons. [D] . Ye, Haihong. 2004

机译：NGF-TrkA信号通路在交感神经元中的功能作用。
6. Ectopic trkA expression mediates a NGF survival response in NGF- independent sensory neurons but not in parasympathetic neurons [O] . 1993

机译：异位trkA表达介导NGF依赖的感觉神经元中的NGF存活反应但在副交感神经元中不介导。
7. Ectopic trkA expression mediates a NGF survival response in NGF- independent sensory neurons but not in parasympathetic neurons [O] . 1993

机译：异位trkA表达介导NGF依赖的感觉神经元中的NGF存活反应，但在副交感神经元中不介导。

NGF - NOT JUST FOR NEURONS [Review]

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