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首页> 外文期刊>Cell biology international. >CYCLE DELAY IN IRRADIATED CYTOCHALASIN-INDUCED POLYKARYONS - DOES CYTOSKELETON STATUS AFFECT CELL CYCLE CHECKPOINTS
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CYCLE DELAY IN IRRADIATED CYTOCHALASIN-INDUCED POLYKARYONS - DOES CYTOSKELETON STATUS AFFECT CELL CYCLE CHECKPOINTS

机译:辐照细胞松弛素诱导的多核细胞的周期延迟-细胞骨架状态是否影响细胞周期检查点

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摘要

Following exposure of CHO-KI cells to Cs-137 irradiation at doses up to 20Gy, a delay in G(2) was observed to occur in cells permitted to divide normally, while cells induced to become giants by means of cytochalasin B demonstrated a minimal delay in the transition 2C - 8C suggesting that the inhibition of cytokinesis results in modification of one or more cell cycle checkpoints. We postulate that this may occur as a consequence of damage tolerance, or by a feedback loop resulting from the reorganisation of the cytoskeleton that precludes cytokinesis.
机译:CHO-KI细胞以最高20Gy的剂量暴露于Cs-137辐照后,观察到在允许正常分裂的细胞中发生了G(2)延迟,而通过细胞松弛素B诱导成为巨细胞的细胞表现出最小的2C-8C过渡的延迟表明胞质分裂的抑制导致一个或多个细胞周期检查点的改变。我们推测,这可能是由于损伤耐受性导致的,或者是由于排除细胞分裂的细胞骨架重组导致的反馈回路而发生的。

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