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首页> 外文期刊>Cell biology international. >CELL CYCLE-DEPENDENT MORPHOLOGICAL CHANGES IN THE ACTIN CYTOSKELETON INDUCED BY AGENTS WHICH ELEVATE CYCLIC AMP
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CELL CYCLE-DEPENDENT MORPHOLOGICAL CHANGES IN THE ACTIN CYTOSKELETON INDUCED BY AGENTS WHICH ELEVATE CYCLIC AMP

机译：电动循环放大器引起的肌动蛋白细胞骨架中细胞周期的形态学变化

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摘要

Agents which increase the intracellular concentration of cyclic adenosine-5'-monophosphate, induce a highly arborised morphology in a proportion of sub-confluent Swiss 3T3 fibroblasts. During this process the organisation of actin filaments progessively changes from a characteristic stress fibre pattern to leave a network of actin filaments within each and every arborisation. Despite this massive reorganisation of the actin cytoskeleton no changes are observed in the extent of polymerisation of actin during arborisation. The proportion of cells in asynchronous cultures undergoing arborisation at maximal concentrations of agents reaches a maximum of 30%; suggesting that the effect might be mediated only in cells during a restricted period of the cell cycle. More than 80% of serum-starved cells responded to these agents between 1 and 8 hours after readdition of serum, but not at other times, suggesting that the arborisation response can occur only in the G1 phase of the cell cycle.
机译：增加细胞内环状腺苷5'-单磷酸浓度的试剂会在部分亚汇合的Swiss 3T3成纤维细胞中诱导高度树状形态。在此过程中，肌动蛋白丝的组织从特征性的应力纤维型式逐渐变化，从而在每个乔木中都留下了肌动蛋白丝网络。尽管肌动蛋白细胞骨架发生了如此大规模的重组，但在树突化过程中并未观察到肌动蛋白聚合程度的变化。在异步培养中，在最大浓度的试剂下进行乔化处理的细胞比例最高达到30％;提示该效应可能仅在细胞周期的有限时期内在细胞中介导。在重新分配血清后1至8小时内，超过80％的血清饥饿细胞对这些试剂有反应，但在其他时间没有反应，这表明树突化反应只能在细胞周期的G1期发生。

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