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首页> 外文期刊>Cell biology international. >MATERNAL NICOTINE EXPOSURE - RESPONSE OF TYPE II PNEUMOCYTES OF NEONATAL RAT PUPS
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MATERNAL NICOTINE EXPOSURE - RESPONSE OF TYPE II PNEUMOCYTES OF NEONATAL RAT PUPS

机译:尼古丁暴露-新生大鼠小白鼠II型肺细胞反应

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摘要

The influence of maternal nicotine exposure during pregnancy and lactation on the Type II cells of lung tissue of one day old neonatal rat pups was investigated. The results clearly show that maternal nicotine exposure resulted in an increase in the type II cell count in the lungs of the offspring. In addition the lamellar body content of the type II cells of the nicotine exposed rat pups were significantly (P < 0.01) higher than that of the control animals. The type II cell mitochondria of lung tissue of nicotine exposed rat pups were swollen and no microvilli occurred on the alveolar surface. This clearly illustrates that nicotine interfered with type II cell integrity of tlte neonatal lung and may subsequently interfere with the normal development of the alveolar region of the lung.
机译:研究了孕期和哺乳期母体尼古丁暴露对一天龄新生幼鼠肺组织II型细胞的影响。结果清楚地表明,母体尼古丁暴露导致后代肺部II型细胞计数增加。此外,暴露于尼古丁的幼犬的II型细胞的片状体含量显着(P <0.01)比对照动物高。暴露于尼古丁的幼犬肺组织的II型细胞线粒体肿胀,肺泡表面未见微绒毛。这清楚地表明,尼古丁会干扰新生儿肺的II型细胞完整性,并随后可能会干扰肺泡区域的正常发育。

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