...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Role of sodium ferulate in the nociceptive sensory facilitation of neuropathic pain injury mediated by P2X(3) receptor.
【24h】

Role of sodium ferulate in the nociceptive sensory facilitation of neuropathic pain injury mediated by P2X(3) receptor.

机译：阿魏酸钠在由P2X（3）受体介导的神经性疼痛损伤的伤害性感觉感觉促进中的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Neuropathic pain usually is persistent and no effective treatment. ATP plays an important role in the initiation of pain. P2X(3) receptors are localized in the dorsal root ganglion (DRG) neurons and activated by extracellular ATP. Sodium ferulate (SF) is an active principle from Chinese herbal medicine and has anti-inflammatory activities. This study observed the effects of SF on the nociceptive facilitation of the primary sensory afferent after chronic constriction injury (CCI) mediated by P2X(3) receptor. In this study, the content of ATP in DRG neurons was measured by high-performance liquid chromatography (HPLC). P2X(3) agonist-activated currents in DRG neurons was recorded by the whole-cell patch-clamp skill. The expression of P2X(3) mRNA in DRG neurons was analyzed by in situ hybridization. The ATP content of DRG was increased after CCI. In CCI rats treated with SF, the content of ATP in DRG neurons was reduced. SF decreased the increment of P2X(3) agonist-activated currents and P2X(3) mRNA expression in DRG neurons during CCI. SF may inhibit the initiation of pain and primary afferent sensitization mediated by P2X(3) receptor during CCI.
机译：神经性疼痛通常是持续性的，没有有效的治疗方法。 ATP在疼痛的产生中起重要作用。 P2X（3）受体位于背根神经节（DRG）神经元，并由细胞外ATP激活。阿魏酸钠（SF）是中草药的有效成分，具有抗炎活性。这项研究观察了SF对P2X（3）受体介导的慢性收缩损伤（CCI）后主要感觉传入的伤害感受促进的影响。在这项研究中，DRG神经元中的ATP含量是通过高效液相色谱（HPLC）测定的。通过全细胞膜片钳技术记录了DRG神经元中的P2X（3）激动剂激活电流。通过原位杂交分析DRG神经元中P2X（3）mRNA的表达。 CCI后DRG的ATP含量增加。在用SF处理的CCI大鼠中，DRG神经元中ATP的含量降低了。 SF降低了CCI期间DRG神经元中P2X（3）激动剂激活电流和P2X（3）mRNA表达的增量。 SF可能会抑制CCI期间P2X（3）受体介导的疼痛和初级传入敏化的启动。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号