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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Developmental changes in the response of murine cerebellar granule cells to nitric oxide.
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Developmental changes in the response of murine cerebellar granule cells to nitric oxide.

机译：小鼠小脑颗粒细胞对一氧化氮反应的发育变化。

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摘要

Nitric oxide is a diffusible messenger that plays a multitude of roles within the nervous system including modulation of cell viability. However, its role in regulating neuronal survival during a defined period of neurodevelopment has never been investigated. We discovered that expression of the messenger RNA for both neuronal and endothelial nitric oxide synthase increased in the early postnatal period in the cerebellum in vivo, whilst the expression of inducible nitric oxide synthase remained constant throughout this time in development. Whilst scavenging of nitric oxide was deleterious to the survival of early postnatal cerebellar granule neurons in vitro, this effect was lost in cultures derived at increasing postnatal ages. Conversely, sensitivity to exogenous nitric oxide increased with advancing postnatal age. Thus, we have shown that as postnatal development proceeds, cerebellar granule cells alter their in vitro survival responses to both nitric oxide inhibition and donation, revealing that the nitric oxide's effects on developing neurons vary with the stage of development studied. These findings have important consequences for our understanding of the role of nitric oxide during neuronal development.
机译：一氧化氮是一种可扩散的信使，在神经系统中起多种作用，包括调节细胞活力。但是，从未研究过它在特定的神经发育时期调节神经元存活的作用。我们发现神经元和内皮一氧化氮合酶的信使RNA的表达在出生后早期在小脑中体内增加，而诱导型一氧化氮合酶的表达在整个开发过程中保持恒定。一氧化氮的清除对体外早期产后小脑颗粒神经元的存活有害，但这种作用在出生后年龄增长的培养物中丧失了。相反，随着出生后年龄的增长，对外源性一氧化氮的敏感性增加。因此，我们已经表明，随着出生后发育的发展，小脑颗粒细胞会改变其对一氧化氮抑制和供体的体外存活反应，从而揭示一氧化氮对发育中的神经元的作用随所研究的发育阶段而变化。这些发现对我们理解一氧化氮在神经元发育过程中的作用具有重要意义。

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