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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Temporal changes in free iron levels after brain ischemia Relevance to the timing of iron chelation therapy in stroke.
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Temporal changes in free iron levels after brain ischemia Relevance to the timing of iron chelation therapy in stroke.

机译：脑缺血后游离铁水平的时间变化与中风铁螯合疗法的时机有关。

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Whereas iron chelators have been proposed as therapeutic agents in stroke, changes in free iron levels have never been explored after focal brain ischemia. Therefore, free and total iron levels in cortical tissue and free iron levels in plasma were measured before and after (1, 4 and 24h) photothrombotic occlusion of cortical vessels in rats. Brain ferritin expression and localization were also investigated before and after (24, 72 and 192h) occlusion. The results showed that free iron remained below detectable levels in plasma and that the lesion exhibited high levels of free and total iron. As compared to contralateral values, free iron levels in ischemic core and penumbra increased (+50%) at 1h and returned to control values at 4h post-occlusion. In contrast, the increase in total iron levels (+20-30%) was long-lasting, but confined to the ischemic core. A time-dependent increase in the expression of both chains of ferritin was detected in regions that previously exhibited free iron accumulation. Finally, ischemic damage was reduced by the liposoluble iron chelator 2,2'-dipyridyl (20mg/kg, i.p.) when injected 15min or 1h post-occlusion, yet not later (4h). In conclusion, our results show that focal brain ischemia results in an early and transient elevation in free iron levels in the ischemic tissue and suggest that free iron excess does not originate in blood. They also highlight the importance of starting iron chelation therapy as soon as possible after stroke.
机译：尽管已经提出铁螯合剂作为中风的治疗剂，但局灶性脑缺血后从未探讨过游离铁水平的变化。因此，在大鼠皮层血管的光栓形成闭塞之前，之后（1、4和24小时）测量了皮质组织中的游离铁和总铁水平以及血浆中的游离铁水平。还在闭塞前后（24、72和192h）研究了脑铁蛋白的表达和定位。结果表明，游离铁保持在血浆中低于可检测水平，并且病变表现出高水平的游离和总铁。与对侧值相比，缺血核心和半影中的游离铁水平在1h时增加（+ 50％），并在闭塞后4h返回到对照值。相比之下，总铁含量的增加（+ 20-30％）是持久的，但仅限于缺血核心。在先前显示自由铁蓄积的区域中检测到铁蛋白两条链的表达随时间的增加。最后，当在闭塞后15min或1h注射脂溶性铁螯合剂2,2'-联吡啶（20mg / kg，i.p.）可以减轻缺血性损伤，但在以后（4h）不能注射。总之，我们的结果表明局灶性脑缺血导致缺血组织中游离铁水平的早期和短暂升高，并表明游离铁过量并非起源于血液。他们还强调了中风后尽快开始铁螯合疗法的重要性。

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