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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Regulation of the neuronal norepinephrine transporter by endothelin-1 and -3 in the rat anterior and posterior hypothalamus.
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Regulation of the neuronal norepinephrine transporter by endothelin-1 and -3 in the rat anterior and posterior hypothalamus.

机译：大鼠前下丘脑和后丘脑中内皮素-1和-3对神经元去甲肾上腺素转运蛋白的调节。

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摘要

We previously reported that endothelin-1 and endothelin-3 modulate norepinephrine neuronal release and tyrosine hydroxylase activity and expression in the hypothalamus. In the present study we sought to establish the role of endothelin-1 and -3 in the regulation of norepinephrine uptake in the anterior and posterior hypothalamus. Results showed that in the anterior hypothalamus endothelin-3 increased neuronal norepinephrine uptake whereas endothelin-1 decreased it. Conversely, in the posterior hypothalamic region both endothelins diminished the neuronal uptake of the amine. Endothelins response was concentration dependent and maintained at all studied times. Endothelins also modified the kinetic and internalization of the NE neuronal transporter. In the anterior hypothalamic region endothelin-3 increased the V(max) and the B(max) whereas endothelin-1 decreased them. However, in the posterior hypothalamic region both endothelins diminished the V(max) as well as B(max). Neither endothelin-1 nor endothelin-3 modified neuronal norepinephrine transporter K(d) in the studied hypothalamic regions. These findings support that in the posterior hypothalamic region both endothelins diminished neuronal norepinephrine transporter activity by reducing the amine transporter expression on the plasmatic membrane. Conversely, in the anterior hypothalamic region endothelin-3 enhanced neuronal norepinephrine transporter activity by increasing the expression of the transporter on the presynaptic membrane, whereas endothelin-1 induced the opposite effect. Present results permit us to conclude that both endothelins play an important role in the regulation of norepinephrine neurotransmission at the presynaptic nerve endings in the hypothalamus.
机译：我们先前曾报道内皮素1和内皮素3调节去甲肾上腺素神经元释放和酪氨酸羟化酶活性以及在下丘脑中的表达。在本研究中，我们试图建立内皮素-1和-3在下丘脑前部和后部去甲肾上腺素摄取调节中的作用。结果显示，在下丘脑前部，内皮素3增加了神经元去甲肾上腺素的摄取，而内皮素1减少了其摄取。相反，在下丘脑后部，两种内皮素都减少了神经元对胺的吸收。内皮素反应是浓度依赖性的，并且在所有研究时间均保持不变。内皮素还修饰了NE神经元转运蛋白的动力学和内在化作用。在下丘脑前区，内皮素3增加了V（max）和B（max），而内皮素-1降低了它们。但是，在下丘脑后部区域，两种内皮素均降低了V（max）和B（max）。在研究的下丘脑区域，内皮素-1和内皮素3均未修饰神经元去甲肾上腺素转运蛋白K（d）。这些发现支持在下丘脑后区域，两种内皮素都通过减少质膜上胺转运蛋白的表达而减少了神经元去甲肾上腺素转运蛋白的活性。相反，在下丘脑前区，内皮素3通过增加突触前膜上转运蛋白的表达来增强神经元去甲肾上腺素转运蛋白的活性，而内皮素1诱导相反的作用。目前的结果使我们得出结论，两种内皮素在下丘脑突触前神经末梢的去甲肾上腺素神经传递的调节中起着重要作用。

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