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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Lysophosphatidylcholine induces delayed myelination in the juvenile ventral hippocampus and behavioral alterations in adulthood.
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Lysophosphatidylcholine induces delayed myelination in the juvenile ventral hippocampus and behavioral alterations in adulthood.

机译：溶血磷脂酰胆碱诱导少年腹侧海马的髓鞘延迟和成年后的行为改变。

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摘要

Maternal virus infection or maternal polyinosinic-polycytidilic acid injection confers behavioral alterations including deficit in prepulse inhibition on the offspring. We previously found delayed myelination specifically in the early postnatal hippocampus in the polyinosinic-polycytidilic acid-injection model. To test whether the transient delay in myelination in the juvenile hippocampus leads to abnormal behaviors after adolescence, we injected lysophosphatidylcholine, a potent demyelinating agent, into the ventral hippocampus of the 10-day-old rat. The lysophosphatidylcholine treatment yielded hypomyelination at postnatal day 16, but myelination reverted to normal level in the adult rat. Neuronal arrays and morphology were not disturbed in this model. We then performed a battery of behavioral tests on the lysophosphatidylcholine-treated and control PBS-injected rats. The lysophosphatidylcholine-treated rats showed deficit in prepulse inhibition, motor hyperactivity in response to methamphetamine andanxiety-related behaviors, all of which are typical behaviors observed in the maternal infection models. These findings suggest that the timing of myelination in the early postnatal hippocampus is crucial for the proper development of sensorimotor and emotional functions. The lysophosphatidylcholine-treated rat without a gross anatomical defect is useful as a model for psychotic disorders.
机译：母体病毒感染或母体多肌苷酸-聚胞苷酸注射具有行为改变，包括对后代的前脉冲抑制能力不足。我们以前在多肌苷酸-聚胞苷酸注射模型中发现了延迟的髓鞘形成，特别是在产后早期海马中。为了测试青春期海马的瞬时髓鞘延迟是否导致异常行为，我们向10日龄大鼠的腹侧海马注射了一种有效的脱髓鞘剂溶血磷脂酰胆碱。溶血磷脂酰胆碱治疗在出生后第16天产生髓鞘减少，但成年大鼠的髓鞘形成恢复到正常水平。在该模型中神经元阵列和形态没有受到干扰。然后，我们对溶血磷脂酰胆碱治疗和注射PBS的大鼠进行了一系列行为测试。溶血磷脂酰胆碱治疗的大鼠表现出前脉冲抑制不足，对甲基苯丙胺有反应的运动亢进和焦虑相关行为，所有这些都是在母体感染模型中观察到的典型行为。这些发现表明，在产后早期海马中进行髓鞘化的时机对于感觉运动和情绪功能的正常发展至关重要。没有明显的解剖缺陷的溶血磷脂酰胆碱治疗的大鼠可用作精神疾病的模型。

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