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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Age-related alterations of Nestin-immunoreactive neurons in rat basal forebrain with aged memory deficit.
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Age-related alterations of Nestin-immunoreactive neurons in rat basal forebrain with aged memory deficit.

机译：老年记忆缺陷大鼠基底前脑Nestin免疫反应性神经元的年龄相关变化。

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摘要

Age-related and aged memory deficit changes in Nestin-immunoreactive (Nestin-IR) neurons were studied following recent evidence of distinct Nestin-IR neurons within adult rat basal forebrain. Morris water maze task assessed spatial learning capacity of 3- and 24-month rats (aged-impaired and aged-unimpaired groups). Nestin-IR neuron distributional and morphological features were investigated by immunohistochemistry and positive neuronal number calculation. Nestin-IR neuron number declined with aging, especially aged-impaired. Significant negative correlations existed between average escape latencies and Nestin-IR neuron number in medial septum-diagonal band of Broca (MS-DBB). Correlations of rostral portion [medial septum (MS) and vertical limb diagonal band (vDB)] were higher than caudal portion [horizontal limb diagonal band (hDB)]. Aged-impaired showed reduced complexity of Nestin-IR neuron dendrite arborization and dendritic length. Nestin-IR astrocyte-like cells appeared scattered among Nestin-IR neurons on some aged-impaired slices. In conclusion, aged-impaired rats showed worse cognitive spatial performance and less Nestin-IR neuronal number compared to aged-unimpaired. Nestin-IR neuronal loss and morphological changes are some pathological characteristics of rat aged basal forebrain and may be important in neurobiological mechanisms of brain aging and aged memory deficit.
机译：最近在成年大鼠基底前脑中有明显的Nestin-IR神经元证据之后，研究了Nestin免疫反应性（Nestin-IR）神经元的年龄相关和老年记忆缺陷变化。莫里斯水迷宫任务评估了3个月和24个月大鼠（年龄受损和年龄未成年组）的空间学习能力。通过免疫组织化学和阳性神经元数量计算研究了巢蛋白-IR神经元的分布和形态特征。 Nestin-IR神经元数目随衰老而下降，尤其是衰老的人。 Broca内侧中隔对角带（MS-DBB）的平均逃避潜伏期与Nestin-IR神经元数量之间存在显着的负相关。鼻部[中隔（MS）和垂直肢体对角带（vDB）]的相关性高于尾部[水平肢体对角带（hDB）]。老年人受损显示Nestin-IR神经元枝晶乔木化和树突长度的复杂性降低。 Nestin-IR星形胶质细胞样细胞出现在一些衰老的切片上的Nestin-IR神经元之间。总之，与未成年的成年大鼠相比，年老的成年大鼠表现出较差的认知空间表现和更少的Nestin-IR神经元数量。 Nestin-IR神经元丢失和形态变化是大鼠老年基底前脑的某些病理特征，可能在脑衰老和老年记忆缺陷的神经生物学机制中起重要作用。

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