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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >High-affinity choline uptake and acetylcholine-metabolizing enzymes in CNS white matter. A quantitative study.
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High-affinity choline uptake and acetylcholine-metabolizing enzymes in CNS white matter. A quantitative study.

机译：中枢神经系统白质中的高亲和力胆碱摄取和乙酰胆碱代谢酶。定量研究。

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摘要

The presence of nicotinic and muscarinic receptors suggests the occurrence of cholinergic neurotransmission in white matter; however no quantitative information exists on acetylcholine formation and breakdown in white matter. We compared white structures of pig brain (fimbria, corpus callosum, pyramidal tracts, and occipital white matter) to gray structures (temporal, parietal and cerebellar cortices, hippocampus, and caudate) and found that sodium-dependent, high-affinity choline uptake in white structures was 25-31% of that in hippocampus. White matter choline acetyltransferase activity was 10-50% of the hippocampal value; the highest activity was found in fimbria. Acetylcholine esterase activity in white structures was 20-25% of that in hippocampus. The caudate, which is rich in cholinergic interneurons, gave values for all three parameters that were 2.8-4 times higher than in hippocampus. The results suggest a certain capacity for cholinergic neurotransmission in central nervous white matter. The white matter activity of pyruvate dehydrogenase, which provides acetyl-CoA for acetylcholine synthesis, ranged between 33 and 50% of the hippocampal activity; the activity in the caudate was similar to that in hippocampus and the other gray structures, which was true also for other enzymes of glucose metabolism: hexokinase, phosphoglucomutase, and glucose-6-phosphate dehydrogenase. Acetylcholine esterase activity in white matter was inhibited by the nerve agent soman, which may help explain the reported deleterious effect of soman on white matter. Further, this finding suggests that acetylcholine esterase inhibitors used in Alzheimer's disease may have an effect in white matter.
机译：烟碱和毒蕈碱受体的存在表明在白质中存在胆碱能神经传递。但是，没有关于乙酰胆碱形成和白质分解的定量信息。我们比较了猪脑的白色结构（毛细血管，call体，锥体束和枕叶白质）与灰色结构（颞叶，顶叶和小脑皮质，海马和尾状），发现钠依赖性，高亲和力的胆碱摄取白色结构占海马结构的25-31％。白质胆碱乙酰转移酶活性为海马值的10-50％;活性最高的是菌毛。白色结构中的乙酰胆碱酯酶活性是海马中的20-25％。尾部富含胆碱能中间神经元，所有三个参数的值均比海马高2.8-4倍。结果表明中枢神经白质具有一定的胆碱能神经传递能力。丙酮酸脱氢酶的白质活性为乙酰胆碱的合成提供了乙酰辅酶A，占海马体活性的33％至50％。尾状核的活性类似于海马和其他灰色结构，葡萄糖代谢的其他酶（己糖激酶，磷酸葡萄糖变位酶和葡萄糖-6-磷酸脱氢酶）也是如此。神经物质梭曼抑制了白质中的乙酰胆碱酯酶活性，这可能有助于解释梭曼对白质的有害作用。此外，该发现表明，用于阿尔茨海默氏病的乙酰胆碱酯酶抑制剂可能对白质有影响。

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