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首页> 外文期刊>Natural product research >A new triterpenoid saponin from Gleditsia sinensis and its antiproliferative activity
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A new triterpenoid saponin from Gleditsia sinensis and its antiproliferative activity

机译：一种新的皂角苷三萜皂苷及其抗增殖活性

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摘要

Chemical investigation of the anomalous fruits of Gleditsia sinensis led to the isolation and identification of a new triterpenoid saponin, 3-O-beta-D-xylopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyl-(1 -> 6)-beta-D-glucopyranosyl oleanolic acid 28-O-beta-D-xylopyranosyl-(1 -> 4)-alpha-L-rhamnopyrano--syl-(1 -> 4)-beta-D-xylopyranosyl-(1 -> 4)-alpha-L-rhamnopyranosyl-(1 -> 3)-beta-D-glucopyranosyl ester (1), along with other nine known compounds (2-10). All the isolates from this species were reported for the first time. The structure of Compound 1 was determined by a detailed analysis using various analytical techniques, including 1D and 2D NMR. In vitro antiproliferative activities of Compound 1 on MCF-7 and Hep-G2 tumor cell lines were evaluated. IC50 values against the two cell lines were 9.5 and 11.6M, respectively.
机译：化学研究的皂荚果异常果实导致分离和鉴定了一种新的三萜皂苷3-O-β-D-吡喃吡喃糖基-（1-> 2）-α-L-阿拉伯吡喃糖基-（1-> 6） -β-D-吡喃葡萄糖基齐墩果酸28-O-β-D-吡喃吡喃糖基-（1-> 4）-α-L-鼠李糖吡喃基-syl-（1-> 4）-β-D-吡喃吡喃糖基-（1- > 4）-α-L-鼠李吡喃糖基-（1-> 3）-β-D-吡喃吡喃糖基酯（1），以及其他九种已知化合物（2-10）。首次报道了该物种的所有分离株。使用各种分析技术，包括1D和2D NMR，通过详细分析确定化合物1的结构。评价了化合物1对MCF-7和Hep-G2肿瘤细胞系的体外抗增殖活性。两种细胞系的IC50值分别为9.5和11.6M。

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