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首页> 外文期刊>Frontiers in neuroendocrinology >Brain aromatase: new lessons from non-mammalian model systems.
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Brain aromatase: new lessons from non-mammalian model systems.

机译:脑芳香化酶:非哺乳动物模型系统的新课程。

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摘要

This review highlights recent studies of the anatomical and functional implications of brain aromatase (estrogen synthase) expression in two vertebrate lineages, teleost fishes and songbirds, that show remarkably high levels of adult brain aromatase activity, protein and gene expression compared to other vertebrate groups. Teleosts and birds have proven to be important neuroethological models for investigating how local estrogen synthesis leads to changes in neural phenotypes that translate into behavior. Region-specific patterns of aromatase expression, and thus estrogen synthesis, include the vocal and auditory circuits that figure prominently into the life history adaptations of vocalizing teleosts and songbirds. Thus, by targeting, for example, vocal motor circuits without inappropriate steroid exposure to other steroid-dependent circuits, such as those involved in either copulatory or spawning behaviors, the neuroendocrine system can achieve temporal and spatial specificity in its modulation of neural circuits that lead to the performance of any one behavior.
机译:这篇综述着重介绍了在两个脊椎动物谱系,硬骨鱼和鸣禽中脑芳香酶(雌激素合酶)表达的解剖学和功能意义的最新研究,与其他脊椎动物组相比,它们显示出成人脑芳香酶的活性,蛋白质和基因表达水平高得多。硬骨鱼和鸟类已被证明是重要的神经行为学模型,用于研究局部雌激素合成如何导致神经表型变化并转化为行为。芳香化酶表达的特定区域模式以及雌激素合成包括发声和听觉回路,这些声音和声音主要体现在发声硬骨鱼和鸣禽的生活史适应中。因此,通过将例如声带运动回路对准目标,而没有使类固醇不适当地暴露于其他类固醇依赖性回路(例如涉及交配或产卵行为的那些回路),神经内分泌系统可以在其调节导致表现任何一种行为。

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