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首页> 外文期刊>Frontiers in neuroendocrinology >Neuroendocrine mechanisms of innate states of attenuated responsiveness of the hypothalamo-pituitary adrenal axis to stress.
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Neuroendocrine mechanisms of innate states of attenuated responsiveness of the hypothalamo-pituitary adrenal axis to stress.

机译：下丘脑-垂体肾上腺轴对应激反应减弱的先天状态的神经内分泌机制。

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摘要

Neuroendocrine responses to stress vary between sexes and reproductive states and are influenced by the type of stressor. Stress responses are attenuated in some physiological states, such as lactation and conditions of low visceral adipose tissue. Moreover, some individuals within a species characteristically display reduced stress responses. The neuroendocrine mechanisms for stress hyporesponsiveness are likely to include reduced synthesis and secretion of corticotropin releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus as a result of enhanced glucocorticoid negative feedback and/or reduced noradrenergic stimulatory input from the brain stem. A major limitation of research to date is the lack of direct measures of CRH and AVP secretion. Attenuated stress responsiveness is also commonly associated with reduced pituitary responsiveness to CRH and AVP. The possible roles of inhibitory central inputs to CRH and AVP neurons and of oxytocin and prolactin in attenuating the HPA axis responses to stress are unknown.
机译：神经内分泌对压力的反应在性别和生殖状态之间有所不同，并受压力源类型的影响。在某些生理状态，例如泌乳和低内脏脂肪组织的状况下，应激反应减弱。此外，物种内的某些个体特征性地表现出降低的应激反应。压力低反应性的神经内分泌机制可能包括由于糖皮质激素负反馈增强和/或脑干去甲肾上腺素能刺激输入减少而导致下丘脑的促肾上腺皮质激素释放激素（CRH）和精氨酸加压素（AVP）的合成和分泌减少。迄今为止，研究的主要局限性是缺乏直接测定CRH和AVP分泌的方法。减轻的应激反应性通常也与垂体对CRH和AVP的反应性降低有关。尚不知道抑制CRH和AVP神经元的中央输入以及催产素和催乳素在减弱HPA轴对应激反应中的作用。

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