Molecular neuroendocrinology, genomics, and proteomics

Vincenzo C. Russo; Sheena Wong; Elena Andaloro; George A. Werther

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Molecular neuroendocrinology, genomics, and proteomics

机译：分子神经内分泌学，基因组学和蛋白质组学

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An early event in the pathogenesis of neuroblastoma (NB) appears to be the arrested differentiation of neuroblasts. We have recently demonstrated that fibroblast growth factor-2 (FGF-2) promotes NB cell differentiation and over-rides the effect of the NB cell mitogen insulin-like growth factor-I (IGF-I). However the molecular mechanisms are unclear.We therefore wished to determine whether FGF-2 induced differentiation of NB cells involves modulation of genes controlling neurogenesis and/or other signaling molecules activated by FGF-2. The expression of ID 1-3 and SOCS1-3 was thus analysed.

机译：神经母细胞瘤（NB）发病机制中的一个早期事件似乎是神经母细胞的分化停止。我们最近证明，成纤维细胞生长因子2（FGF-2）促进NB细胞分化，并超越了NB细胞有丝分裂原胰岛素样生长因子I（IGF-1）的作用。然而，分子机制尚不清楚。因此，我们希望确定FGF-2诱导的NB细胞分化是否涉及控制神经发生和/或被FGF-2激活的其他信号分子的基因的调节。因此分析了ID 1-3和SOCS1-3的表达。

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《Frontiers in neuroendocrinology》 |2006年第1期|共5页
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Vincenzo C. Russo; Sheena Wong; Elena Andaloro; George A. Werther;
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中图分类神经病学与精神病学;
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Molecular neuroendocrinology, genomics, and proteomics

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