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首页> 外文期刊>Frontiers in neuroendocrinology >Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: complexity of steroid hormone-growth factor interactions in the adult CNS.
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Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: complexity of steroid hormone-growth factor interactions in the adult CNS.

机译：海马中的雌激素和脑源性神经营养因子（BDNF）：成年中枢神经系统中类固醇激素-生长因子相互作用的复杂性。

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摘要

In the CNS, there are widespread and diverse interactions between growth factors and estrogen. Here we examine the interactions of estrogen and brain-derived neurotrophic factor (BDNF), two molecules that have historically been studied separately, despite the fact that they seem to share common targets, effects, and mechanisms of action. The demonstration of an estrogen-sensitive response element on the BDNF gene provided an impetus to explore a direct relationship between estrogen and BDNF, and predicted that the effects of estrogen, at least in part, might be due to the induction of BDNF. This hypothesis is discussed with respect to the hippocampus, where substantial evidence has accumulated in favor of it, but alternate hypotheses are also raised. It is suggested that some of the interactions between estrogen and BDNF, as well as the controversies and implications associated with their respective actions, may be best appreciated in light of the ability of BDNF to induce neuropeptide Y (NPY) synthesis in hippocampal neurons. Taken together, this tri-molecular cascade, estrogen-BDNF-NPY, may be important in understanding the hormonal regulation of hippocampal function. It may also be relevant to other regions of the CNS where estrogen is known to exert profound effects, such as amygdala and hypothalamus; and may provide greater insight into neurological disorders and psychiatric illness, including Alzheimer's disease, depression and epilepsy.
机译：在中枢神经系统中，生长因子和雌激素之间存在广泛而多样的相互作用。在这里，我们检查了雌激素和脑源性神经营养因子（BDNF）的相互作用，这两个分子在历史上曾分别进行过研究，尽管它们似乎具有共同的靶标，作用和作用机制。在BDNF基因上的雌激素敏感反应元件的证明为探索雌激素和BDNF之间的直接关系提供了动力，并预测雌激素的作用至少部分是由于BDNF的诱导。关于海马体讨论了这一假设，在海马体上已经积累了大量的证据，但也提出了其他假设。建议根据BDNF诱导海马神经元中神经肽Y（NPY）合成的能力，最好地了解雌激素和BDNF之间的某些相互作用以及与其各自作用有关的争议和影响。总之，这种三分子级联的雌激素-BDNF-NPY，可能对理解海马功能的激素调节很重要。它也可能与中枢神经系统中已知雌激素会产生深远影响的其他区域有关，例如杏仁核和下丘脑;并且可以提供对神经系统疾病和精神疾病（包括阿尔茨海默氏病，抑郁症和癫痫病）的更深入的了解。

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