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首页> 外文期刊>Frontiers in neuroendocrinology >Cross-talk between estrogen receptors and insulin-like growth factor-I receptor in the brain: cellular and molecular mechanisms.
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Cross-talk between estrogen receptors and insulin-like growth factor-I receptor in the brain: cellular and molecular mechanisms.

机译：大脑中雌激素受体和胰岛素样生长因子-I受体之间的串扰：细胞和分子机制。

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摘要

Accumulating evidence suggests that insulin-like growth factor-I (IGF-I) and estradiol interact to regulate neural function. In this review, we focus on the cellular and molecular mechanisms involved in this interaction. The expression of estrogen receptors (ERs) and IGF-I receptor is cross-regulated in the central nervous system and many neurons and astrocytes coexpress both receptors. Furthermore, estradiol activates IGF-I receptor and its intracellular signaling. This effect may involve classical ERs since recent findings suggest that ERalpha may affect IGF-I actions in the brain by a direct interaction with some of the components of IGF-I signaling. In turn, IGF-I may regulate ER transcriptional activity in neuronal cells. In conclusion, ERs appear to be part of the signaling mechanism of IGF-I, and IGF-I receptor part of the mechanism of estradiol signaling in the nervous system.
机译：越来越多的证据表明，胰岛素样生长因子-I（IGF-I）和雌二醇相互作用调节神经功能。在这篇综述中，我们专注于这种相互作用涉及的细胞和分子机制。雌激素受体（ERs）和IGF-I受体的表达在中枢神经系统中相互调节，许多神经元和星形胶质细胞共同表达这两种受体。此外，雌二醇激活IGF-1受体及其细胞内信号传导。这种作用可能涉及经典的ER，因为最近的发现表明ERalpha可能通过与IGF-1信号传导的某些成分直接相互作用而影响大脑中IGF-1的作用。反过来，IGF-I可能调节神经元细胞中的ER转录活性。总之，ERs似乎是IGF-I信号传导机制的一部分，而IGF-I受体是神经系统中雌二醇信号传导机制的一部分。

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