...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Frontiers in neuroendocrinology >Metastin and its G protein-coupled receptor, GPR54: critical pathway modulating GnRH secretion.
【24h】

Metastin and its G protein-coupled receptor, GPR54: critical pathway modulating GnRH secretion.

机译：Metastin及其G蛋白偶联受体GPR54：调节GnRH分泌的关键途径。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Photoperiod, food availability, temperature, stress, and hormonal cues are some of the varied signals used by mammalian species to activate or suppress their timing of sexual maturation. All ultimately converge upon gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus. Through its stimulation of LH and FSH from the pituitary, GnRH represents a critical step in the reproductive cascade. While few dispute this central role of GnRH, little is understood of the mechanisms influencing the developmental fate and physiologic controls of GnRH neurons. Identification of the signals which modulate pulsatile GnRH secretion is critical to advancing understanding of normal puberty and reproductive competency. The recent identification of loss-of-function mutations in GPR54, a receptor for kisspeptin-1, has highlighted a new pathway for the timing of puberty and reproductive control.
机译：光周期，食物供应，温度，压力和激素提示是哺乳动物物种用来激活或抑制其性成熟时机的各种信号。所有这些最终都收敛于下丘脑的促性腺激素释放激素（GnRH）分泌。通过从垂体刺激LH和FSH，GnRH代表了生殖级联反应中的关键步骤。尽管很少有人质疑GnRH神经元的这种核心作用，但对影响GnRH神经元发育命运和生理控制的机制了解甚少。鉴定调节搏动性GnRH分泌的信号对于增进对正常青春期和生殖能力的了解至关重要。最近鉴定出的kisspeptin-1受体GPR54中的功能丧失突变，突显了青春期和生殖控制时机的新途径。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号