Fast glucocorticoid actions on brain: back to the future.

Dallman MF

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Fast glucocorticoid actions on brain: back to the future.

机译：快速糖皮质激素对大脑的作用：回到未来。

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Rapid, non-transcriptionally mediated, effects of glucocorticoids affect many behaviors as well as inhibition of function in the hypothalamo-pituitary-adrenal axis. In this short review, it is argued that the fast glucocorticoid actions which are mediated by membrane receptors are an ancient type of sterol/steroid-mediated effect, and that these may be the primordial glucocorticoid receptors. Although the fast feedback actions of the glucocorticoids enjoyed study in the middle of the last century, new results and the availability of new techniques suggest that it is again time for a concerted effort to be made to understand the mechanism(s) of these rapid effects.

机译：糖皮质激素的快速非转录介导作用会影响许多行为，并抑制下丘脑-垂体-肾上腺轴的功能。在这篇简短的综述中，有人认为由膜受体介导的快速糖皮质激素作用是一种古老的固醇/类固醇介导的作用，并且可能是原始的糖皮质激素受体。尽管糖皮质激素的快速反馈作用在上世纪中叶得到了研究，但新的结果和新技术的可用性表明，现在该再次作出一致的努力来了解这些快速作用的机制。。

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《Frontiers in neuroendocrinology》 |2005年第4期|共6页
作者
Dallman MF;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Feedback; Biochemical; Glucocorticoids; Hypothalamo-Hypophyseal System; Pituitary-Adrenal System; 糖皮质激素类; 下丘脑-垂体系统; 垂体肾上腺系统; 受体; 细胞表面;

机译：Feedback;Biochemical;Glucocorticoids;Hypothalamo-Hypophyseal System;Pituitary-Adrenal System;糖皮质激素类;下丘脑-垂体系统;垂体肾上腺系统;受体;细胞表面;

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6. Distinct Ontogeny of Glucocorticoid and Mineralocorticoid Receptor and 11β-Hydroxysteroid Dehydrogenase Types I and II mRNAs in the Fetal Rat Brain Suggest a Complex Control of Glucocorticoid Actions [O] . Rochellys Diaz, Roger W. Brown, Jonathan R. Seckl 1998

机译：胎鼠脑中糖皮质激素和盐皮质激素受体以及11β-羟类固醇脱氢酶I和II型mRNA的不同个体发育表明糖皮质激素作用的复杂控制
7. Distinct Ontogeny of Glucocorticoid and Mineralocorticoid Receptor and 11β-Hydroxysteroid Dehydrogenase Types I and II mRNAs in the Fetal Rat Brain Suggest a Complex Control of Glucocorticoid Actions [O] . Rochellys Diaz, Roger W. Brown, Jonathan R. Seckl 1998

机译：牙科素皮质激素和矿物质激素受体和11β-羟类脱氢酶类型I和II mRNA在胎儿大鼠脑中的明显组织内显示出糖皮质激素作用的复杂控制

Fast glucocorticoid actions on brain: back to the future.

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