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首页> 外文期刊>Frontiers in neuroendocrinology >Is mom too sensitive? Impact of maternal stress during gestation.
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Is mom too sensitive? Impact of maternal stress during gestation.

机译：妈妈太敏感了吗孕期孕产妇压力的影响。

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Studies have documented the detrimental impact of gestational and postpartum maternal stress on the developing offspring. In susceptible individuals, stress has been associated with everything from brain developmental delays to emotionality and behavior disorders. Understanding the genetics and developmental window of greatest stress sensitivity is vital to providing the best preventative care and therapeutic targets. Corticotropin-releasing factor (CRF) and its receptors (CRFR1 and CRFR2) are the key regulators of the endocrine stress response and are critical in maintenance of organismal homeostasis. Dysregulation of these stress pathways can result in an increased sensitivity to stress. Mice deficient for CRFR2 show such a dysregulation and have been found to be a valuable genetic model of increased stress sensitivity. Initial comparisons utilizing this mouse model in studies examining maternal behaviors and cross-fostering outcome validate the complex nature-nurture contribution. Using this model, altered stress responsivity in offspring appears to require both a genetic predisposition to stress sensitivity and a postnatal environment that influences it.
机译：研究已证明妊娠和产后母体压力对发育中的后代的有害影响。在易感人群中，压力与从大脑发育延迟到情绪和行为障碍的所有因素有关。了解最大压力敏感性的遗传学和发育窗口对于提供最佳的预防保健和治疗目标至关重要。促肾上腺皮质激素释放因子（CRF）及其受体（CRFR1和CRFR2）是内分泌应激反应的关键调节剂，对维持机体动态平衡至关重要。这些应激途径的失调可导致对应激的敏感性增加。缺乏CRFR2的小鼠表现出这种失调，并且被发现是增加应激敏感性的有价值的遗传模型。在研究孕产妇行为和交叉培养结果的研究中，利用这种小鼠模型进行的初步比较证实了复杂的自然养育作用。使用这种模型，后代改变的应激反应性似乎既需要遗传易感性，又需要影响其的出生后环境。

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