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首页> 外文期刊>Frontiers in neuroendocrinology >Cortisol pulsatility and its role in stress regulation and health.
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Cortisol pulsatility and its role in stress regulation and health.

机译：皮质醇搏动性及其在压力调节和健康中的作用。

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摘要

One of the classic characteristics of the human stress response is the wide inter-individual variation. Although there is much current interest in the genetic and environmental contributions to these differences, studies on human subject have been sparse and characterised by methodological problems. The major factor that is rarely taken into account is the intrinsic rhythmicity of hypothalamo-pituitary-adrenal activity, not simply the classic diurnal variation but also the endogenous pulsatility which is similar to, but much less well recognized than, the rhythms found within the reproductive and growth hormone axes. In this review we propose some novel ideas relating to the importance of pulsatility both for the design of human stress-response studies and for their interpretation as well as implications for our understanding of disease.
机译：人类压力反应的经典特征之一是个体之间的广泛差异。尽管目前对引起这些差异的遗传和环境贡献引起了广泛关注，但对人类主题的研究却很少，而且存在方法学问题。很少考虑的主要因素是下丘脑-垂体-肾上腺活动的固有节律性，不仅是经典的昼夜变化，而且还有内源性搏动，其与生殖内发现的节律相似但远没有被充分认识和生长激素轴。在这篇综述中，我们提出了一些关于搏动性的重要性的新颖思想，这些思想对于人类应激反应研究的设计，它们的解释以及对我们对疾病的理解都有影响。

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