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首页> 外文期刊>Frontiers in neuroendocrinology >Molecular determinants and physiological relevance of extrasomatic RNA localization in neurons.
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Molecular determinants and physiological relevance of extrasomatic RNA localization in neurons.

机译：神经元中体外RNA定位的分子决定因素和生理相关性。

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摘要

Specific sorting of mRNA molecules to subcellular microdomains is an evolutionarily conserved mechanism by which the polarized nature of eukayotic cells may be established and maintained. The molecular composition of the RNA localization machinery is complex. Sequence motifs within RNA molecules to be transported, called cis-acting elements, and proteins, referred to as trans-acting factors, are essential components. Transport of the resulting ribonucleoprotein complexes to distinct cytoplasmic regions occurs along the cytoskeletal network. The pathway is observed in organisms as diverse as yeast and human and it plays a critical role in development and cell differentiation. Moreover, RNA localization takes place in differentiated cell types including neurons. There is ample evidence to suggest that sorting of defined mRNA species to the neurites of nerve cells and on-site translation has an impact on various aspects of nerve cell biology.
机译：mRNA分子对亚细胞微区的特异性分选是一种进化保守的机制，通过该机制可以建立和维持真核细胞的极化性质。 RNA定位机制的分子组成很复杂。要运输的RNA分子内的序列基序（称为顺式作用元件）和蛋白质（称为反式作用因子）是必不可少的成分。沿细胞骨架网络将所得核糖核蛋白复合物转运至不同的胞质区域。在酵母和人类等多种生物中均观察到该途径，并且在发育和细胞分化中起着至关重要的作用。此外，RNA定位发生在包括神经元在内的分化细胞类型中。有足够的证据表明，将已定义的mRNA种类分类到神经细胞的神经突和就地翻译会对神经细胞生物学的各个方面产生影响。

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