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首页> 外文期刊>Frontiers in neuroendocrinology >G-protein coupled receptor oligomerization in neuroendocrine pathways.
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G-protein coupled receptor oligomerization in neuroendocrine pathways.

机译：神经内分泌途径中的G蛋白偶联受体寡聚。

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摘要

Protein-protein interactions are fundamental processes for many biological systems including those involving the superfamily of G-protein coupled receptors (GPCRs). A growing body of biochemical and functional evidence supports the existence of GPCR-GPCR homo- and hetero-oligomers. In particular, hetero-oligomers can display pharmacological and functional properties distinct from those of the homodimer or oligomer thus adding another level of complexity to how GPCRs are activated, signal and traffick in the cell. Dimerization may also play a role in influencing the activity of agonists and antagonists. We are only beginning to unravel how and why such complexes are formed, the functional implications of which will have an enormous impact on GPCR biology. Future research that studies GPCRs as dimeric or oligomeric complexes will enhance not only our understanding of GPCRs in cellular function but will also be critical for novel drug design and improved treatment of the vast array of GPCR-related conditions.
机译：蛋白质-蛋白质相互作用是许多生物系统的基本过程，包括涉及G蛋白偶联受体（GPCR）超家族的生物系统。越来越多的生化和功能证据支持GPCR-GPCR均聚物和杂聚物的存在。特别地，杂合寡聚物可以显示不同于同二聚体或寡聚物的药理学和功能特性，从而为细胞中GPCR的激活，信号传递和运输增加了另一层次的复杂性。二聚化也可能在影响激动剂和拮抗剂的活性中起作用。我们才刚刚开始阐明如何形成复合物以及为什么形成复合物，其功能含义将对GPCR生物学产生巨大影响。未来将GPCRs研究为二聚体或寡聚体复合物的研究不仅将增强我们对GPCRs在细胞功能方面的理解，而且对于新药设计和改善多种GPCR相关病症的治疗也将至关重要。

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