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首页> 外文期刊>Frontiers in neuroendocrinology >Transgenic studies on the regulation of the anterior pituitary gland function by the hypothalamus.
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Transgenic studies on the regulation of the anterior pituitary gland function by the hypothalamus.

机译:下丘脑调节垂体前叶功能的转基因研究。

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摘要

The anterior pituitary gland is composed of five different cell types secreting hormones whose functions include the regulation of post-natal growth (growth hormone, GH), lactation (prolactin, PRL), reproduction (luteinising hormone, LH, and follicle stimulating hormone, FSH), metabolism (thyroid stimulating hormone, TSH), and stress (adrenocorticotrophic hormone, ACTH). The synthesis and secretion of the anterior pituitary hormones is under the control of neuropeptides released from the hypothalamus into a capillary portal plexus which flows through the external zone of the median eminence to the anterior lobe. This review describes the ways that gene transfer technologies have been applied to whole animals in order to study the regulation of anterior pituitary function by the hypothalamus. The extensive studies on these neuronal systems, within the context of the physiological integrity of the intact organism, not only exemplify the successful application of transgenic technologies to neuroendocrine systems, but also illustrate the problems that have been encountered, and the challenges that lie ahead.
机译:垂体前叶由分泌激素的五种不同细胞类型组成,其功能包括调节产后生长(生长激素,GH),泌乳(催乳素,PRL),生殖(促黄体生成素,LH和促卵泡激素,FSH) ),新陈代谢(促甲状腺激素,促甲状腺激素)和应激(促肾上腺皮质激素,促肾上腺皮质激素)。垂体前叶激素的合成和分泌受下丘脑释放到毛细血管门丛中的神经肽的控制,毛细血管丛经正中隆起的外部区域流到前叶。这篇综述描述了将基因转移技术应用于整个动物的方式,以研究下丘脑对垂体前叶功能的调节。在完整生物的生理完整性范围内,对这些神经元系统的广泛研究不仅说明了转基因技术在神经内分泌系统中的成功应用,而且还说明了所遇到的问题以及未来的挑战。

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