Mechanisms underlying episodic gonadotropin-releasing hormone secretion.

Moenter SM; Anthony DeFazio R; Pitts GR; Nunemaker CS

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Mechanisms underlying episodic gonadotropin-releasing hormone secretion.

机译：促性腺激素释放激素分泌的基础机制。

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The episodic secretion of gonadotropin-releasing hormone (GnRH) is crucial for fertility, but the cellular mechanisms and network properties generating GnRH pulses are not well understood. We will explore three primary aspects of this intermittent hormonal signal: the source of rhythm(s), the possible mechanisms comprising oscillator(s), and how GnRH neurons are synchronized to produce a pulse of hormone release into the pituitary portal blood. Current knowledge will be reviewed, and hypotheses and working models proposed for future studies.

机译：促性腺激素释放激素（GnRH）的阵发分泌对于生育至关重要，但产生GnRH脉冲的细胞机制和网络特性尚不十分清楚。我们将探讨这种间歇性激素信号的三个主要方面：节律的来源，可能的振荡机制，以及GnRH神经元如何同步产生将激素释放到垂体门脉的信号。将审查当前的知识，并提出假设和工作模型以供将来研究。

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《Frontiers in neuroendocrinology》 |2003年第2期|共15页
作者
Moenter SM; Anthony DeFazio R; Pitts GR; Nunemaker CS;
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正文语种 eng
中图分类神经病学与精神病学;内分泌腺疾病及代谢病;
关键词
Gonadorelin; Process of secretion; Mechanisms; Discharge (release); 促性腺素释放激素;

机译：Gonadorelin;Process of secretion;Mechanisms;Discharge (release);促性腺素释放激素;

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1. Mechanisms underlying episodic gonadotropin-releasing hormone secretion. [J] . Moenter SM, Anthony DeFazio R, Pitts GR, Frontiers in neuroendocrinology . 2003,第2期

机译：促性腺激素释放激素分泌的基础机制。
2. Secretion of luteinizing hormone into pituitary venous effluent of the follicular and luteal phase mare: novel acceleration of episodic release during constant infusion of gonadotropin-releasing hormone [J] . Velez I. C., Pack J. D., Porter M. B., Domestic Animal Endocrinology . 2012,第3期

机译：黄体生成素分泌到卵泡和黄体期垂体的垂体静脉流出物中：不断注入促性腺激素释放激素期间新的突发释放
3. Hyperandrogenaemia in adolescent girls: origins of abnormal gonadotropin-releasing hormone secretion. [J] . Burt Solorzano CM, McCartney CR, Blank S BJOG: an international journal of obstetrics and gynaecology . 2010,第2期

机译：少女高雄激素血症：促性腺激素释放激素分泌异常的起源。
4. Using prostaglandin F2a and gonadotropin-releasing hormone simultaneously 7 d prior to Ovsynch increased first-service pregnancies per artificial insemination compared to Presynch-14/Ovsynch [C] . Annual Conference of The American Association of Bovine Practitioners . 2018

机译：在Ovsynch之前同时使用前列腺素F2A和促性腺激素释放激素在Ovsynch之前同时进行7天，而与PRESYNCH-14 / OVSYNCH相比，每个人工授精的第一阶段性妊娠增加
5. Central control of reproduction: Mechanisms of kisspeptin actions on gonadotropin-releasing hormone neurons: intrinsic, network properties and their sensitivity to estradiol. [D] . Pielecka-Fortuna, Justyna. 2010

机译：生殖的中央控制：亲吻肽对促性腺激素释放激素神经元的作用机制：内在，网络特性及其对雌二醇的敏感性。
6. Modeling and high-throughput experimental data uncover the mechanisms underlying Fshb gene sensitivity to gonadotropin-releasing hormone pulse frequency [O] . Estee Stern, Frederique Ruf-Zamojski, Lisa Zalepa-King, 2017

机译：建模和高通量实验数据揭示了Fshb基因对促性腺激素释放激素脉冲频率敏感的潜在机制
7. Modeling and high-throughput experimental data uncover the mechanisms underlying Fshb gene sensitivity to gonadotropin-releasing hormone pulse frequency [O] . Estee Stern, Frederique Ruf-Zamojski, Lisa Zalepa-King, 2017

机译：建模和高通量实验数据揭示了FSHB基因敏感性促进促性腺激素释放激素脉冲频率的机制

Mechanisms underlying episodic gonadotropin-releasing hormone secretion.

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