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首页> 外文期刊>Frontiers in neuroendocrinology >Development of gonadotropin-releasing hormone-1 neurons.
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Development of gonadotropin-releasing hormone-1 neurons.

机译：促性腺激素释放激素-1神经元的发展。

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摘要

Gonadotropin releasing hormone-1 (GnRH-1) neurons, critical for reproduction, are derived from the nasal placode and migrate into the brain during prenatal development. Once within the brain, GnRH-1 cells become integral components of the CNS-pituitary-gonadal axis, essential for reproductive maturation and maintenance of reproductive function in adults. This review focuses on the lineage and development of the GnRH-1 neuroendocrine system. Although the migration of these cells from nose to brain has been well documented in a variety of species, many questions remain concerning the melecules and cues directing GnRH-1 cell differentiation, migration, axon targeting, and establishment and control of GnRH-1 secretion. These process most likely involve multiple and redundant cues because if these mechanisms fail, reproduction dysfunction will ensue and guarantee that this defect does not remain in the gene pool.
机译：对生殖至关重要的促性腺激素释放激素-1（GnRH-1）神经元来自鼻斑，并在产前发育期间迁移到大脑中。一旦进入大脑，GnRH-1细胞就成为CNS-垂体-性腺轴的组成部分，对成人的生殖成熟和维持其生殖功能至关重要。这篇综述集中于GnRH-1神经内分泌系统的沿袭和发展。尽管这些细胞从鼻子到大脑的迁移已在许多物种中得到了充分的文献证明，但仍存在许多有关指导GnRH-1细胞分化，迁移，轴突靶向以及建立和控制GnRH-1分泌的分子和线索的问题。这些过程很可能涉及多个和多余的线索，因为如果这些机制失败，则会发生繁殖功能障碍，并确保该缺陷不会保留在基因库中。

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