...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Frontiers in neuroendocrinology >Regulation of gene promoters of hypothalamic peptides.
【24h】

Regulation of gene promoters of hypothalamic peptides.

机译：下丘脑肽基因启动子的调控。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In order to fulfill their roles in neuroendocrine regulation, specific hypothalamic neurons are devoted to produce and deliver biologically active peptides to the pituitary gland. The biosynthesis and release of peptides are strictly controlled by afferents to these hypothalamic neurons. Cell-specific expression and biosynthetic regulation largely relies on transcription from the gene promoter for which the 5(')-flanking regions of the peptidergic genes contain essential elements. Cell-specific transcription factors employ these regulatory elements to exert their control over the expression of the peptidergic gene. This article explores the properties of regulatory elements of the major hypothalamic peptides, somatostatin, growth hormone-releasing hormone, gonadotropin-releasing hormone, thyrotropin-releasing hormone, corticotropin-releasing hormone, vasopressin and oxytocin, and the transcription factors acting on them. These transcription factors are often endpoints of signal transduction pathways that can be activated by neurotransmitters or steroid hormones. Others are essential to provide cell-specific expression of the peptidergic gene during development and mature regulation.
机译：为了履行其在神经内分泌调节中的作用，特定的下丘脑神经元致力于产生生物活性肽并将其传递至垂体。这些下丘脑神经元的传入细胞严格控制肽的生物合成和释放。细胞特异性表达和生物合成调节主要依赖于基因启动子的转录，而肽能基因的5（'）侧翼区含有必需元件。细胞特异性转录因子利用这些调节元件来控制肽能基因的表达。本文探讨了主要下丘脑肽，生长抑素，生长激素释放激素，促性腺激素释放激素，促甲状腺激素释放激素，促肾上腺皮质激素释放激素，血管加压素和催产素的调控元件的特性，以及作用于它们的转录因子。这些转录因子通常是信号传导途径的终点，可以被神经递质或类固醇激素激活。在发育和成熟调节过程中，其他一些对于提供肽能基因的细胞特异性表达至关重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号