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首页> 外文期刊>Frontiers in neuroendocrinology >Diverse actions of ovarian steroids in the serotonin neural system.
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Diverse actions of ovarian steroids in the serotonin neural system.

机译：卵巢甾体在5-羟色胺神经系统中的不同作用。

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All of the serotonin-producing neurons of the mammalian brain are located in 10 nuclei in the mid- and hindbrain regions. The cells of the rostal nuclei project to almost every area of the forebrain and regulate diverse neural processes from higher order functions in the prefrontal cortex such as integrative cognition and memory, to limbic system control of arousal and mood, to diencephalic functions such as pituitary hormone secretion, satiety, and sexual behavior. The more caudal serotonin neurons project to the spinal cord and interact with numerous autonomic and sensory systems. All of these neural functions are sensitive to the presence or absence of the ovarian hormones, estrogen and progesterone. We have shown that serotonin neurons in nonhuman primates contain estrogen receptor beta and progestin receptors. Thus, they are targets for ovarian steroids which in turn modify gene expression. Any change in serotoninergic neural function could be manifested by a change in any of the projection target systems and in this manner, serotonin neurons integrate steroid hormone information and partially transduce their action in the CNS. This article reviews the work conducted in this laboratory on the actions of estrogens and progestins in the serotonin neural system of nonhuman primates. Comparisons to results obtained in other laboratory animal models are made when available and limited clinical data are referenced. The ability of estrogens and progestins to alter the function of the serotonin neural system at various levels provides a cellular mechanism whereby ovarian hormones can impact cognition, mood or arousal, hormone secretion, pain, and other neural circuits.
机译：哺乳动物脑中所有产生5-羟色胺的神经元都位于中脑和后脑区域的10个核中。地壳核的细胞投射到前脑的几乎每个区域，并调节各种神经过程，从前额叶皮质的高阶功能（例如整合认知和记忆）到边缘系统的唤醒和情绪控制，再到脑功能（例如垂体激素）分泌，饱腹感和性行为。尾部5-羟色胺神经元更多地投射到脊髓，并与众多的自主神经和感觉系统相互作用。所有这些神经功能对卵巢激素，雌激素和孕激素的存在或缺乏敏感。我们已经表明，非人类灵长类动物中的血清素神经元含有雌激素受体β和孕激素受体。因此，它们是卵巢类固醇的靶标，其继而修饰基因表达。 5-羟色胺能神经功能的任何改变都可以通过任何投射目标系统的改变来体现，并且以这种方式，5-羟色胺神经元整合了类固醇激素信息并部分转导了它们在中枢神经系统中的作用。本文回顾了在该实验室中有关雌激素和孕激素在非人类灵长类动物5-羟色胺神经系统中的作用的工作。比较可获得的其他实验室动物模型中获得的结果，并参考有限的临床数据。雌激素和孕激素在不同水平改变5-羟色胺神经系统功能的能力提供了一种细胞机制，由此卵巢激素可以影响认知，情绪或唤醒，激素分泌，疼痛和其他神经回路。

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