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首页> 外文期刊>Frontiers in neuroendocrinology >Implications of multiple phenotypes observed in prolactin receptor knockout mice.
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Implications of multiple phenotypes observed in prolactin receptor knockout mice.

机译：在催乳素受体基因敲除小鼠中观察到多种表型的含义。

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The development of a mouse line deficient in the PRL receptor (PRLR) would be an ideal means to better understand the multiple functions of prolactin. We were worried initially that removal of the PRLR from the mouse genome might be lethal and were surprised to find this not to be the case. We identified numerous deficiencies in PRLR knockout (KO) animals. Female homozygous mice are completely infertile and lack normal mammary development, while hemizygotes are unable to lactate following their first pregnancy. PRLR KO males and females have markedly elevated (30- to 100-fold) serum prolactin levels and in some instances pituitary hyperplasia is present. Maternal behavior is severely affected in both hemizygous and heterozygous animals. Bone formation is reduced in young animals and adults (males and females). Recently, we noticed that older KO animals show a slight reduction in body weight which appears to be due to reduced abdominal fat deposition. Copyright 2001 Academic Press.
机译：缺乏PRL受体（PRLR）的小鼠系的发展将是理想的手段，以更好地了解催乳激素的多种功能。最初，我们担心从小鼠基因组中删除PRLR可能致命，并惊讶地发现情况并非如此。我们发现了PRLR基因敲除（KO）动物的许多缺陷。雌性纯合小鼠完全不育，并且缺乏正常的乳腺发育，而半合子在第一次怀孕后就无法泌乳。 PRLR KO男性和女性的血清催乳素水平明显升高（30到100倍），在某些情况下还存在垂体增生。在半合子和杂合子动物中，母亲的行为都受到严重影响。幼小动物和成年动物（雄性和雌性）的骨形成减少。最近，我们注意到年长的KO动物的体重略有下降，这似乎是由于腹部脂肪沉积减少所致。版权所有2001学术出版社。

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