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首页> 外文期刊>Frontiers in neuroendocrinology >Neuroendocrine tumor markers.
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Neuroendocrine tumor markers.

机译:神经内分泌肿瘤标志物。

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摘要

Tumor markers used in the diagnosis and follow-up of patients with neuroendocrine tumors are in most instances not specific for a given tumor and circulate under normal conditions in the serum, making their use as an early diagnostic tool difficult (low sensitivity). By combining hormone measurements with tissue responsiveness, demonstrations of inappropriate secretions of PTH, insulin, and gastrin during hypercalcemia, hypoglycemia, and hyperacidity, respectively, become highly sensitive and specific diagnostic tests. The application of polyclonal antibodies in RIAs of hormones, such as ACTH, insulin, and gastrin, increase the diagnostic level of hormone measurements in patients with neuroendocrine tumors. Other markers, such as chromogranin A, neuron-specific enolase, and alpha-subunit, as well as peptide receptor visualization, are of increasing importance in the diagnosis and follow-up of neuroendocrine and non-neuroendocrine tumors.
机译:在大多数情况下,神经内分泌肿瘤患者的诊断和随访中使用的肿瘤标记物对特定的肿瘤不是特异性的,并且在正常条件下会在血清中循环,因此很难用作早期诊断工具(灵敏度低)。通过将激素测量结果与组织反应性结合起来,分别证明高钙血症,低血糖症和高酸血症期间PTH,胰岛素和胃泌素分泌异常,变得高度敏感和特异。在激素(如ACTH,胰岛素和胃泌素)的RIA中应用多克隆抗体可提高神经内分泌肿瘤患者激素测量的诊断水平。其他标记物,例如嗜铬粒蛋白A,神经元特异性烯醇化酶和α-亚基,以及肽受体可视化,在神经内分泌和非神经内分泌肿瘤的诊断和随访中越来越重要。

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