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首页> 外文期刊>Frontiers in neuroendocrinology >Progesterone receptors as neuroendocrine integrators.
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Progesterone receptors as neuroendocrine integrators.

机译：孕激素受体作为神经内分泌的整合剂。

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Intracellular progesterone receptors (PRs) are ligand-inducible transcription factors that mediate the majority of the effects of progesterone (P) on neuroendocrine functions. During the past decade, evidence has accumulated which suggest that PRs can also be activated independently of P, by signals propagated through membrane-bound receptors to the interior of cells. The activation of PRs by this type of "cross-talk" mechanism has been implicated in the physiological regulation of several important neuroendocrine processes, including estrous behavior and periovulatory hormone secretions. We review evidence that both ligand-dependent and ligand-independent activation of PRs occurs in central neurons and in anterior pituitary cells and that the convergence and summation of these signals at the PR serves to integrate neural and endocrine signals which direct several critically important neuroendocrine processes. An integrative function for PRs is reviewed in several physiological contexts, including the display of lordosis behavior in female rodents, the neurosecretion of gonadotropin-releasing hormone surges, secretion of preovulatory gonadotropin surges, and release of periovulatory follicle stimulating hormone surges. The weight of evidence indicates that cross talk at the intracellular PR is an essential component of the integrative mechanisms that direct each of these neuroendocrine events. The recurrence of PR's integrative actions in several different physiological contexts suggests that other intracellular steroid receptors similarly function as integrators of neural and endocrine signals in other neuroendocrine processes. Copyright 2001 Academic Press.
机译：细胞内孕激素受体（PRs）是配体诱导的转录因子，可介导孕激素（P）对神经内分泌功能的大部分作用。在过去的十年中，已经积累了证据表明PRs也可以通过膜结合受体传播到细胞内部的信号独立于P活化。通过这种“串扰”机制激活PRs已牵涉到几种重要的神经内分泌过程的生理调节，包括发情行为和排卵周激素分泌。我们审查的证据表明，PRs的配体依赖性和配体依赖性激活均发生在中枢神经元和垂体前叶细胞中，并且这些信号在PR处的收敛和求和用于整合神经和内分泌信号，从而指导几个至关重要的神经内分泌过程。 PRs的整合功能在几种生理环境中得到了审查，包括在雌性啮齿动物中表现出脊柱前凸行为，促性腺激素释放激素激增的神经分泌，促排卵前促性腺激素激增的分泌以及促排卵周卵泡刺激性激素激增的释放。大量证据表明，细胞内PR的串扰是指导这些神经内分泌事件中每一个事件的整合机制的重要组成部分。 PR在多种不同生理环境中的整合作用的复发表明，其他细胞内类固醇受体在其他神经内分泌过程中也类似地充当神经和内分泌信号的整合剂。版权所有2001，学术出版社。

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